Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6893210 | 0.96 | KDM4E (0.43) | KDM4EMEN1NPC1MAPTRAB9A | |
| SCHEMBL6894246 | 0.85 | MEN1 (0.43) | KDM4EMEN1NPC1MAPTRAB9A | |
| SCHEMBL10234081 | 0.85 | TRPA1 (0.42) | KDM4EMEN1NPC1MAPTRAB9A | |
| SCHEMBL6894598 | 0.82 | CSNK2A1 (0.41) | KDM4EMEN1NPC1MAPTRAB9A | |
| SCHEMBL6893201 | 0.82 | PIM1 (0.41) | KDM4EMEN1NPC1MAPTRAB9A | |
| SCHEMBL6893465 | 0.81 | PIK3CA (0.39) | KDM4EMEN1NPC1MAPTRAB9A | |
| SCHEMBL6894058 | 0.81 | MAPT (0.50) | KDM4EMEN1NPC1MAPTRAB9A | |
| SCHEMBL6893199 | 0.80 | MAPT (0.47) | KDM4EMEN1NPC1MAPTRAB9A | |
| SCHEMBL6893413 | 0.79 | MAPT (0.44) | KDM4EMEN1NPC1MAPTRAB9A | |
| SCHEMBL10234075 | 0.79 | CHEK1 (0.46) | KDM4EMEN1NPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |