Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 5/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | GRM5 | P41594 | 7/20 | 0.37 |
| ▸ | CLPP | Q16740 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30795442 | 0.90 | GRM5 (0.40) | HCRTR1HCRTR2RAB9AGRM5CLPP | |
| SCHEMBL601066 | 0.90 | GRM5 (0.40) | HCRTR1HCRTR2RAB9AGRM5CLPP | |
| SCHEMBL599528 | 0.79 | GRM5 (0.50) | HCRTR1HCRTR2GRM5CLPPL3MBTL1 | |
| SCHEMBL600492 | 0.78 | PROKR1 (0.42) | HCRTR1HCRTR2RAB9AGRM5NPC1 | |
| SCHEMBL599809 | 0.78 | GRM5 (0.47) | HCRTR1HCRTR2RAB9AGRM5CLPP | |
| SCHEMBL600389 | 0.78 | GRM5 (0.40) | HCRTR1HCRTR2GRM5CLPP | |
| SCHEMBL1971652 | 0.78 | RAB9A (0.57) | RAB9AGRM5CLPPL3MBTL1MEN1 | |
| SCHEMBL1971645 | 0.78 | RAB9A (0.57) | RAB9AGRM5CLPPL3MBTL1MEN1 | |
| SCHEMBL1975121 | 0.77 | GRM5 (0.57) | RAB9AGRM5CLPPL3MBTL1MEN1 | |
| SCHEMBL1975119 | 0.77 | GRM5 (0.57) | RAB9AGRM5CLPPL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010124055-A1 | 2-ALKYL PIPERIDINE MGLUR5 RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-28 | — | — | WO | disclosed |