Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | TYK2 | P29597 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.36 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL438772 | 0.83 | NTRK1 (0.45) | RHEBNPC1RAB9AATMERAP1 | |
| SCHEMBL5009107 | 0.80 | RHEB (0.44) | RHEBNPC1RAB9AATMERAP1 | |
| SCHEMBL5009086 | 0.78 | RHEB (0.41) | RHEBNPC1RAB9AATMERAP1 | |
| SCHEMBL441639 | 0.78 | RHEB (0.45) | RHEBNPC1RAB9AATMERAP1 | |
| Hydrochloric Acid SCHEMBL5006204 | 0.77 | RHEB (0.40) | RHEBNPC1RAB9AATMERAP1 | |
| SCHEMBL453373 | 0.77 | NTRK1 (0.44) | RHEBNPC1RAB9AATMERAP1 | |
| SCHEMBL439680 | 0.75 | NTRK1 (0.61) | RHEBNPC1RAB9AATMERAP1 | |
| SCHEMBL441645 | 0.75 | RHEB (0.43) | RHEBNPC1RAB9AATMERAP1 | |
| SCHEMBL438747 | 0.74 | RHEB (0.41) | RHEBNPC1RAB9AATMERAP1 | |
| SCHEMBL5131647 | 0.74 | PDE3B (0.56) | RHEBNPC1RAB9AATMERAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037155-A2 | TYROSINE KINASE INHIBITORS | GTX, INC. (US) | 2012-03-22 | — | — | WO | disclosed |