SCHEMBL7876510

SCHEMBL7876510

C[C@@H](OCc1ccccc1)[C@H](N)C(=O)Nc1nccs1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PKM P14618 1/20 0.55
LMNA P02545 4/20 0.54
TSHR P16473 2/20 0.54
HSPA5 P11021 2/20 0.52
HSPA9 P38646 2/20 0.52
HSPA1A P0DMV8 1/20 0.52
HSPA2 P54652 1/20 0.52
CYP1A2 P05177 1/20 0.51
CYP3A4 P08684 1/20 0.51
CYP2D6 P10635 1/20 0.51
CYP2C9 P11712 1/20 0.51
CYP2C19 P33261 1/20 0.51
HSD17B10 Q99714 1/20 0.50
KDM4E B2RXH2 1/20 0.50
HDAC6 Q9UBN7 1/20 0.48
XBP1 P17861 1/20 0.48
SMN1; SMN2 Q16637 2/20 0.48
NPC1 O15118 2/20 0.48
RAB9A P51151 2/20 0.48
L3MBTL1 Q9Y468 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7868134 0.87 LMNA (0.49) PKMLMNATSHRHSPA5HSPA9
SCHEMBL7873410 0.82 LMNA (0.50) PKMLMNATSHRHSPA5HSPA9
SCHEMBL6056801 0.79 LMNA (0.51) LMNATSHRHSPA5HSPA9HSPA2
Hydrochloric Acid SCHEMBL7381658 0.78 LMNA (0.50) LMNATSHRHSPA5HSPA9HSPA2
SCHEMBL24815318 0.76 SLC1A2 (0.53) CYP1A2CYP2D6CYP2C9CYP2C19SMN1; SMN2
SCHEMBL7284299 0.76 SLC1A2 (0.53) CYP1A2CYP2D6CYP2C9CYP2C19SMN1; SMN2
SCHEMBL5556446 0.76 SLC1A2 (0.53) CYP1A2CYP2D6CYP2C9CYP2C19SMN1; SMN2
SCHEMBL29178320 0.76 SLC1A2 (0.53) CYP1A2CYP2D6CYP2C9CYP2C19SMN1; SMN2
SCHEMBL24815315 0.76 SLC1A2 (0.53) CYP1A2CYP2D6CYP2C9CYP2C19SMN1; SMN2
SCHEMBL7868173 0.76 LMNA (0.56) LMNATSHRHSPA5HSPA9HSPA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6329400-B1 INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS GLAXO WELLCOME INC. 2001-12-11 US disclosed