Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 3/20 | 0.33 |
| ▸ | CA2 | P00918 | 3/20 | 0.33 |
| ▸ | CA9 | Q16790 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CA3 | P07451 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7867743 | 0.90 | PTGS2 (0.46) | PTGS2PTGS1KDM4CKDM5BSMPD1 | |
| SCHEMBL8072072 | 0.87 | PTGS2 (0.45) | PTGS2PTGS1KDM4CKDM5BSMPD1 | |
| SCHEMBL7876568 | 0.85 | POLB (0.46) | PTGS2PTGS1LMNAMEN1KMT2A | |
| SCHEMBL7872834 | 0.85 | PTGS2 (0.46) | PTGS2PTGS1KDM4CKDM5BCA1 | |
| SCHEMBL7872931 | 0.82 | PTGS2 (0.46) | PTGS2PTGS1KDM4CKDM5BCA1 | |
| SCHEMBL7878950 | 0.82 | PTGS2 (0.43) | PTGS2PTGS1KDM4CKDM5B | |
| SCHEMBL9202494 | 0.79 | PTGS2 (0.52) | PTGS2PTGS1LMNAMAPK14MEN1 | |
| SCHEMBL8645116 | 0.79 | MALT1 (0.50) | PTGS2PTGS1SMPD1CYP2C9CYP3A4 | |
| SCHEMBL7465856 | 0.77 | PTGS2 (0.54) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL7867785 | 0.77 | PTGS2 (0.47) | PTGS2PTGS1CA9PDPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316485-B1 | INHIBITS ACTIVITY OF CYCLOOXYGENASE-2; FOR THERAPY AND PROPHYLAXIS OF INFLAMMATION, THROMBOSIS, RHEUMATOID ARTHRITIS, ALZHEIMER'S DISEASE; AS ANALGESIC | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |