Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 11/20 | 0.75 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.75 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.63 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.63 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.63 |
| ▸ | DRD2 | P14416 | 7/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7881150 | 0.91 | HTR1A (0.90) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL7882933 | 0.88 | HTR1A (0.70) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL7884119 | 0.88 | HTR1A (0.73) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL7881258 | 0.87 | SLC6A4 (0.68) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL7887563 | 0.86 | HTR1A (0.72) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL7876565 | 0.86 | HTR1A (0.72) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL7881295 | 0.86 | HTR1A (0.81) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL7885642 | 0.86 | HTR1A (0.72) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL7883019 | 0.84 | HTR1A (0.60) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL7883007 | 0.82 | HTR1A (0.67) | HTR1ASLC6A4ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172073-B1 | BENZIMIDAZOLYLOXY ALKANAMINES AS SEROTONIN REUPTAKE INHIBITORS; NICOTINE AND TOBACCO WITHDRAWAL; PSYCHOLOGICAL, EATING, BRAIN, GASTROINTESTINAL, SLEEP, AND SEXUAL DISORDERS | ELI LILLY AND COMPANY | 2001-01-09 | — | — | US | disclosed |
| US-5789402-A | Compounds having effects on serotonin-related systems | ELI LILLY COMPANY (US) | 1998-08-04 | — | — | US | disclosed |
| US-5741789-A | HETERO-OXY ALKANAMINES | ELI LILLY AND COMPANY (US) | 1998-04-21 | — | — | US | disclosed |
| US-5627196-A | ANTIDEPRESSANTS AND ANTISEROTONIN AGENTS | ELI LILLY AND COMPANY (US) | 1997-05-06 | — | — | US | disclosed |
| US-5614523-A | INDOLYLOXY COMPOUNDS | ELI LILLY AND COMPANY (US) | 1997-03-25 | — | — | US | disclosed |
| US-5576321-A | ALKOXY-SUBSTITUTED INDOLES | ELI LILLY AND COMPANY (US) | 1996-11-19 | — | — | US | disclosed |
| EP-0722941-A2 | Compounds having effects on serotonin-related systems | ELI LILLY AND COMPANY (US) | 1996-07-24 | — | — | EP | disclosed |