Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 5/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 6/20 | 0.38 |
| ▸ | CA2 | P00918 | 6/20 | 0.38 |
| ▸ | CA12 | O43570 | 5/20 | 0.38 |
| ▸ | CA9 | Q16790 | 5/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7883263 | 0.80 | HDAC1 (0.41) | HDAC1MAPKAPK2KDM4AL3MBTL1CA1 | |
| SCHEMBL27559509 | 0.77 | KDM4E (0.41) | HDAC1KDM4AL3MBTL1KCNA5CA1 | |
| SCHEMBL6500881 | 0.76 | KDM4A (0.40) | HDAC1MAPKAPK2KDM4AL3MBTL1KCNA5 | |
| SCHEMBL4599344 | 0.76 | KDM4A (0.44) | HDAC1KDM4AL3MBTL1KCNA5CA1 | |
| SCHEMBL6681076 | 0.74 | MAPK1 (0.45) | HDAC1MAPKAPK2KDM4AL3MBTL1KCNA5 | |
| SCHEMBL654820 | 0.74 | KDM4A (0.45) | HDAC1KDM4AL3MBTL1KCNA5CA1 | |
| SCHEMBL24168226 | 0.73 | SYK (0.40) | KCNA5CA1CA2CA12CA9 | |
| SCHEMBL29467981 | 0.73 | RPS6KA1 (0.42) | HDAC1KDM4AL3MBTL1KCNA5CA1 | |
| SCHEMBL7878669 | 0.72 | POLB (0.41) | HDAC1MAPKAPK2KDM4AL3MBTL1CA1 | |
| SCHEMBL15171404 | 0.72 | NPC1 (0.52) | KDM4AL3MBTL1KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331553-B1 | INHIBITORS OF NITRIC OXIDE SYNTHASE; TREATING CEREBROVASCULAR DISEASES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2001-12-18 | — | — | US | disclosed |
| EP-0949242-A1 | AROMATIC AMINE DERIVATIVES HAVING NOS INHIBITORY EFFECT | Chugai Seiyaku Kabushiki Kaisha (JP) | 1999-10-13 | — | — | EP | disclosed |