Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | STK17B | O94768 | 1/20 | 0.37 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7883263 | 0.88 | HDAC1 (0.41) | HDAC1L3MBTL1MAPKAPK2KDM4ALMNA | |
| SCHEMBL27530730 | 0.83 | POLB (0.41) | POLBMAPK1ATMHDAC1L3MBTL1 | |
| SCHEMBL14907839 | 0.78 | POLB (0.53) | POLBMAPK1ATMHDAC1MAPKAPK2 | |
| SCHEMBL21484075 | 0.77 | POLB (0.59) | POLBMAPK1ATMTSHRSMN1; SMN2 | |
| SCHEMBL29726432 | 0.73 | TSHR (0.56) | HDAC1L3MBTL1TSHRSMN1; SMN2GAA | |
| SCHEMBL3101649 | 0.73 | TSHR (0.56) | POLBMAPK1HDAC1L3MBTL1TSHR | |
| SCHEMBL964473 | 0.73 | TSHR (0.56) | HDAC1L3MBTL1TSHRSMN1; SMN2GAA | |
| SCHEMBL7876697 | 0.72 | HDAC1 (0.39) | HDAC1L3MBTL1MAPKAPK2KDM4ACA1 | |
| SCHEMBL31432271 | 0.72 | HDAC1 (0.46) | POLBMAPK1HDAC1L3MBTL1TSHR | |
| SCHEMBL31432272 | 0.72 | HDAC1 (0.46) | POLBMAPK1HDAC1L3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331553-B1 | INHIBITORS OF NITRIC OXIDE SYNTHASE; TREATING CEREBROVASCULAR DISEASES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2001-12-18 | — | — | US | disclosed |
| EP-0949242-A1 | AROMATIC AMINE DERIVATIVES HAVING NOS INHIBITORY EFFECT | Chugai Seiyaku Kabushiki Kaisha (JP) | 1999-10-13 | — | — | EP | disclosed |