Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 7/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4413263 | 0.86 | CNR2 (0.50) | ALDH1A1TDP1CNR2KMT2APSMB8 | |
| SCHEMBL4411439 | 0.86 | KMT2A (0.56) | KEAP1NFE2L2ALDH1A1MAPTTDP1 | |
| SCHEMBL4413648 | 0.86 | TDP1 (0.59) | HTTALDH1A1HPGDTDP1CNR2 | |
| SCHEMBL4420755 | 0.85 | POLB (0.54) | ALDH1A1MAPTHPGDCNR2KMT2A | |
| SCHEMBL4410938 | 0.81 | MEN1 (0.54) | HTTALDH1A1MAPTKMT2AKDM4E | |
| SCHEMBL4565762 | 0.81 | ELANE (0.54) | KMT2A | |
| SCHEMBL4413017 | 0.81 | SMN1; SMN2 (0.44) | HTTMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL4418491 | 0.79 | ALDH1A1 (0.48) | HTTALDH1A1MAPTHPGDTDP1 | |
| SCHEMBL6321028 | 0.78 | EPHX2 (0.46) | HTTALDH1A1HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL4423219 | 0.78 | ALDH1A1 (0.53) | HTTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6333351-B1 | ENZYME INHIBITORS WITH CARRIERS | ATHENA NEUROSCIENCES, INC. | 2001-12-25 | — | — | US | claimed |