Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.52 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.52 |
| ▸ | ITGAL | P20701 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7868578 | 1.00 | ALDH1A1 (0.67) | ALDH1A1ITGB2ICAM1ITGALSMN1; SMN2 | |
| SCHEMBL7876933 | 0.81 | SMN1; SMN2 (0.52) | SMN1; SMN2MAPK1HTTLMNANPC1 | |
| SCHEMBL7875258 | 0.80 | SMN1; SMN2 (0.52) | SMN1; SMN2MAPK1HTTLMNANPC1 | |
| SCHEMBL7877262 | 0.79 | GAA (0.65) | ALDH1A1SMN1; SMN2MAPK1HTTLMNA | |
| SCHEMBL10858265 | 0.79 | ALDH1A1 (0.79) | ALDH1A1ITGB2ICAM1ITGALSMN1; SMN2 | |
| SCHEMBL10858272 | 0.79 | ALDH1A1 (0.79) | ALDH1A1ITGB2ICAM1ITGALSMN1; SMN2 | |
| SCHEMBL7873773 | 0.78 | SMN1; SMN2 (0.49) | SMN1; SMN2MAPK1HTTLMNANPC1 | |
| SCHEMBL7879569 | 0.75 | QPCT (0.49) | ALDH1A1SMN1; SMN2LMNAMAPTNPC1 | |
| SCHEMBL7868601 | 0.75 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2MAPK1HTTLMNA | |
| SCHEMBL8949297 | 0.75 | SMN1; SMN2 (0.52) | ALDH1A1SMN1; SMN2MAPK1HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6326500-B1 | ANTIINFLAMMATORY AGENTS; ANTIALLERGENS | ABBOTT LABORATORIES | 2001-12-04 | — | — | US | disclosed |
| US-6215001-B1 | ANTIINFLAMMATORY AGENTS, ANTIASTHMATICS, AND ANTIALLERGENS; SIDE EFFECT REDUCTION | KNOLL AKTIENGESELLSCHAFT (DE) | 2001-04-10 | — | — | US | disclosed |
| US-6031109-A | Phenoxy-, phenylthio-, benzoyl-alkyleneaminoalkylene-imidazole derivatives as therapeutic agents | KNOLL AKTIENGESELLSCHAFT (DE) | 2000-02-29 | — | — | US | disclosed |
| US-5780642-A | NON-STEROIDAL ANTIINFLAMMATORY AGENT WHICH BLOCKS RELEASE OF ARACHIDONIC ACID FROM PHOSPHOLIPIDS; SIDE EFFECT REDUCTION | KNOLL AKTIENGESELLSCHAFT (DE) | 1998-07-14 | — | — | US | disclosed |
| WO-1995000493-A1 | IMIDAZOLE DERIVATIVES AS THERAPEUTIC AGENTS | KNOLL AG (DE) | 1995-01-05 | — | — | WO | disclosed |