Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH1 | P20839 | 16/20 | 0.60 |
| ▸ | IMPDH2 | P12268 | 13/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7877371 | 1.00 | IMPDH1 (0.60) | IMPDH1IMPDH2KDM4EALDH1A1LMNA | |
| SCHEMBL9084374 | 1.00 | IMPDH1 (0.60) | IMPDH1IMPDH2KDM4EALDH1A1LMNA | |
| SCHEMBL1153362 | 1.00 | IMPDH1 (0.60) | IMPDH1IMPDH2KDM4EALDH1A1LMNA | |
| SCHEMBL8544680 | 0.97 | IMPDH1 (0.58) | IMPDH1IMPDH2KDM4EALDH1A1LMNA | |
| SCHEMBL1153706 | 0.97 | IMPDH1 (0.58) | IMPDH1IMPDH2KDM4EALDH1A1LMNA | |
| SCHEMBL1152618 | 0.91 | IMPDH1 (0.73) | IMPDH1IMPDH2KDM4EALDH1A1LMNA | |
| SCHEMBL8546506 | 0.91 | IMPDH1 (0.58) | IMPDH1IMPDH2KDM4EALDH1A1LMNA | |
| SCHEMBL7881557 | 0.89 | IMPDH2 (0.56) | IMPDH1IMPDH2KDM4EALDH1A1LMNA | |
| SCHEMBL1152769 | 0.89 | IMPDH2 (0.56) | IMPDH1IMPDH2KDM4EALDH1A1LMNA | |
| SCHEMBL1152764 | 0.89 | IMPDH2 (0.56) | IMPDH1IMPDH2KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745075-B1 | 6-SUBSTITUTED MYCOPHENOLIC AND DERIVATIVES WITH IMMUNOSUPPRESSIVE ACTIVITY | SYNTEX LLC (US) | 2001-12-05 | — | — | EP | disclosed |
| EP-0745073-B1 | 5-SUBSTITUTED DERIVATIVES OF MYCOPHENOLIC ACID | SYNTEX INC (US) | 2000-07-12 | — | — | EP | disclosed |
| US-5554612-A | IMMUNOSUPPRESSANTS, VIRICIDES, ANTITUMOR AND ANTIINFLAMMATORY AGENTS | SYNTEX INC (US) | 1996-09-10 | — | — | US | disclosed |
| US-5536747-A | ENZYME INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1996-07-16 | — | — | US | disclosed |
| US-5525602-A | TREATING INFLAMMATORY DISEASES, PREVENTING ALLOGRAFT REJECTION, AUTOIMMUNE DISEASES | SYNTEX (U.S.A.) INC. (US) | 1996-06-11 | — | — | US | disclosed |
| US-5493030-A | CHEMICAL INTERMEDIATES | SYNTEX (U.S.A.) INC. (US) | 1996-02-20 | — | — | US | disclosed |
| WO-1995022534-A1 | 4-AMINO 6-SUBSTITUTED MYCOPHENOLIC ACID AND DERIVATIVES WITH IMMUNOSUPPRESSIVE ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1995-08-24 | — | — | WO | disclosed |
| WO-1995022538-A1 | 5-SUBSTITUTED DERIVATIVES OF MYCOPHENOLIC ACID | SYNTEX (U.S.A.) INC. (US) | 1995-08-24 | — | — | WO | disclosed |
| WO-1995022536-A1 | 6-SUBSTITUTED MYCOPHENOLIC AND DERIVATIVES WITH IMMUNOSUPPRESSIVE ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1995-08-24 | — | — | WO | disclosed |
| US-5444072-A | Useful in treatment of autoimmune disorders, psoriasis, inflammatory diseases, rheumatoid arthritis | SYNTEX (U.S.A.) INC. (US) | 1995-08-22 | — | — | US | disclosed |