Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 14/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7877530 | 0.98 | ACHE (0.50) | ACHEALDH1A1EPHX1ATM | |
| SCHEMBL8769630 | 0.84 | ACHE (0.56) | ACHEALDH1A1EPHX1ATM | |
| Bromide SCHEMBL7873155 | 0.81 | ACHE (0.46) | ACHEALDH1A1EPHX1 | |
| SCHEMBL8645448 | 0.81 | ACHE (0.53) | ACHEALDH1A1EPHX1 | |
| SCHEMBL8195570 | 0.81 | ACHE (0.53) | ACHEALDH1A1EPHX1ATM | |
| SCHEMBL337339 | 0.81 | ACHE (0.53) | ACHEALDH1A1EPHX1ATM | |
| SCHEMBL3627549 | 0.78 | ACHE (0.58) | ACHEALDH1A1EPHX1ATM | |
| SCHEMBL3645511 | 0.77 | EPHX2 (0.53) | ACHE | |
| SCHEMBL5217196 | 0.77 | ACHE (0.56) | ACHEALDH1A1EPHX1ATM | |
| SCHEMBL30473390 | 0.77 | ACHE (0.56) | ACHEALDH1A1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE37438-E1 | Acetamidine derivatives and their use as inhibitors for the nitric oxide synthase | GLAXO WELLCOME INC. | 2001-11-06 | — | — | US | disclosed |
| US-5866612-A | Acetamidine derivatives and their use as inhibitors for the nitric oxide synthase | GLAXO WELLCOME INC. (US) | 1999-02-02 | — | — | US | disclosed |
| EP-0799191-A1 | ACETAMIDINE DERIVATIVES AND THEIR USE AS INHIBITORS FOR THE NITRIC OXIDE SYNTHASE | THE WELLCOME FOUNDATION LIMITED (GB) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996019440-A1 | ACETAMIDINE DERIVATIVES AND THEIR USE AS INHIBITORS FOR THE NITRIC OXIDE SYNTHASE | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-06-27 | — | — | WO | disclosed |