Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 3/20 | 0.37 |
| ▸ | SLC1A5 | Q15758 | 4/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7879999 | 0.91 | SLC6A4 (0.46) | RHEBSLC6A4HTR2AKCNH2SLC6A2 | |
| SCHEMBL7880770 | 0.88 | CYP3A4 (0.40) | RHEBSLC6A4HTR2AKCNH2SLC6A2 | |
| SCHEMBL7878265 | 0.88 | SCN9A (0.37) | RHEBSLC1A5SLC6A4SLC6A2SCN9A | |
| SCHEMBL7885059 | 0.88 | MDM4 (0.33) | RHEBSLC1A5 | |
| SCHEMBL7884259 | 0.85 | RHEB (0.36) | RHEBSLC6A4HTR2A | |
| SCHEMBL7881963 | 0.84 | PPARG (0.38) | RHEB | |
| SCHEMBL7880009 | 0.84 | RHEB (0.42) | RHEBCYP3A4CYP2D6CYP3A5CYP2C19 | |
| SCHEMBL7882108 | 0.83 | SLC6A2 (0.34) | SLC1A5SLC6A4HTR2AKCNH2SLC6A2 | |
| SCHEMBL7884288 | 0.83 | MEN1 (0.38) | RHEBSLC6A4HTR2AKCNH2CYP3A4 | |
| SCHEMBL7879914 | 0.83 | ALDH1A1 (0.31) | RHEB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248772-B1 | HYPOTENSIVE AGENTS; ANTIARRHYTHMIA AGENTS; ANTIDIABETIC AGENTS; ANTIPROLIFERATIVE AGENTS | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2001-06-19 | — | — | US | disclosed |
| US-6169107-B1 | USEFUL FOR THE TREATMENT AND PREVENTION OF DISEASES CAUSED BY INCREASED SODIUM/PROTON (NA.SUP.+ /H.SUP.+) EXCHANGER ACTIVITY, FOR EXAMPLE, HYPERTENSION, ARRHYTHMIA, ANGINA PECTORIS, CARDIAC HYPERTROPHY, DIABETES MELLITUS | SUMITOMO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-0708091-A2 | Indoloylguanidine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-04-24 | — | — | EP | disclosed |