Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.42 |
| ▸ | NEK2 | P51955 | 3/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.38 |
| ▸ | AXL | P30530 | 5/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7875473 | 0.85 | BRAF (0.41) | AAK1NEK2BRD4PAK1KDR | |
| SCHEMBL3705033 | 0.81 | AAK1 (0.47) | AAK1NEK2BRD4GSK3BNPC1 | |
| SCHEMBL297839 | 0.81 | AAK1 (0.45) | AAK1NEK2BRD4GSK3BNPC1 | |
| SCHEMBL7869103 | 0.80 | BRAF (0.49) | NEK2PAK1KDRPLK4AURKA | |
| SCHEMBL7876453 | 0.80 | BTK (0.42) | AAK1NEK2BRD4GSK3BPAK1 | |
| SCHEMBL298022 | 0.79 | PAK1 (0.48) | AAK1NEK2BRD4GSK3BNPC1 | |
| SCHEMBL297306 | 0.79 | BRAF (0.45) | AAK1NEK2BRD4GSK3BNPC1 | |
| SCHEMBL3698741 | 0.78 | AAK1 (0.53) | AAK1NEK2BRD4GSK3BNPC1 | |
| SCHEMBL7880244 | 0.78 | BRAF (0.44) | NEK2PAK1KDRPLK4AURKA | |
| SCHEMBL7874309 | 0.78 | EGFR (0.44) | LMNAKDREGFRFGFR1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129570-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | PLEXXIKON, INC. (US) | 2010-11-11 | — | — | WO | disclosed |