Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 18/20 | 0.47 |
| ▸ | PPARA | Q07869 | 10/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9286066 | 1.00 | PPARG (0.47) | PPARGPPARAFFAR1CYP3A4CYP2C9 | |
| SCHEMBL9274342 | 1.00 | PPARG (0.47) | PPARGPPARAFFAR1CYP3A4CYP2C9 | |
| SCHEMBL7877637 | 1.00 | PPARG (0.47) | PPARGPPARAFFAR1CYP3A4CYP2C9 | |
| SCHEMBL7879128 | 1.00 | PPARG (0.47) | PPARGPPARAFFAR1CYP3A4CYP2C9 | |
| SCHEMBL7871522 | 0.89 | PPARG (0.46) | PPARGPPARAFFAR1CYP3A4CYP2C9 | |
| SCHEMBL7871527 | 0.89 | PPARG (0.46) | PPARGPPARAFFAR1CYP3A4CYP2C9 | |
| SCHEMBL9520977 | 0.88 | PPARG (0.45) | PPARGPPARA | |
| SCHEMBL9721218 | 0.86 | PPARG (0.55) | PPARGPPARA | |
| SCHEMBL8459921 | 0.85 | PPARG (0.41) | PPARGPPARAPPARD | |
| SCHEMBL170065 | 0.84 | PPARG (0.63) | PPARGPPARACYP3A4CYP2C9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641338-A1 | HYPOGLYCEMIC THIAZOLIDINEDIONES AND INTERMEDIATES | PFIZER INC. (US) | 1995-03-08 | — | — | EP | claimed |
| WO-1993002079-A1 | HYPOGLYCEMIC THIAZOLIDINEDIONES AND INTERMEDIATES | PFIZER INC. (US) | 1993-02-04 | — | — | WO | claimed |
| US-6329408-B1 | HYPOCHOLESTEROLEMIC AGENTS; OPTICALLY PURE | PFIZER INC. | 2001-12-11 | — | — | US | disclosed |
| EP-0640089-B1 | ENANTIOSELECTIVE OXAZABOROLIDINE CATALYSTS | PFIZER (US) | 1996-12-27 | — | — | EP | disclosed |
| US-5552548-A | Enantioselective oxazaborolidine catalysts | PFIZER INC. (US) | 1996-09-03 | — | — | US | disclosed |
| EP-0332332-B1 | HYPOGLYCEMIC THIAZOLIDINEDIONE DERIVATIVES | PFIZER INC. (US) | 1993-03-31 | — | — | EP | disclosed |
| US-5130379-A | Anticholesterol agents and antidiabetic agents | PFIZER INC. (US) | 1992-07-14 | — | — | US | disclosed |
| US-5036079-A | Anticholesterol | PFIZER INC. (US) | 1991-07-30 | — | — | US | disclosed |
| WO-1991003474-A1 | HYPOGLYCEMIC THIAZOLIDINEDIONE DERIVATIVES | PFIZER INC. (US) | 1991-03-21 | — | — | WO | disclosed |
| WO-1989008651-A1 | HYPOGLYCEMIC THIAZOLIDINEDIONE DERIVATIVES | PFIZER INC. (US) | 1989-09-21 | — | — | WO | disclosed |
| EP-0332332-A1 | Hypoglycemic thiazolidinedione derivatives | PFIZER INC. (US) | 1989-09-13 | — | — | EP | disclosed |