Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | FDPS | P14324 | 11/20 | 0.33 |
| ▸ | GGPS1 | O95749 | 7/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.31 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9183342 | 0.93 | TSHR (0.33) | SMN1; SMN2FDPSTSHRALDH1A1 | |
| SCHEMBL366645 | 0.86 | TSHR (0.38) | FDPSGGPS1TSHRCES2LPAR1 | |
| SCHEMBL28930082 | 0.84 | TSHR (0.40) | FDPSGGPS1TSHRCES2LPAR1 | |
| SCHEMBL28191748 | 0.84 | TSHR (0.40) | FDPSGGPS1TSHRCES2LPAR1 | |
| SCHEMBL10029661 | 0.84 | TSHR (0.40) | FDPSGGPS1TSHRCES2LPAR1 | |
| SCHEMBL9912385 | 0.84 | TSHR (0.40) | FDPSGGPS1TSHRCES2LPAR1 | |
| SCHEMBL20967951 | 0.84 | TSHR (0.40) | FDPSGGPS1TSHRCES2LPAR1 | |
| SCHEMBL12208739 | 0.84 | TSHR (0.40) | FDPSGGPS1TSHRCES2LPAR1 | |
| SCHEMBL9186812 | 0.84 | — | — | |
| Boric Acid SCHEMBL27917318 | 0.83 | FDPS (0.33) | FDPSGGPS1TSHRCES2LPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6174888-B1 | POTENT PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITORS; INHIBITORS OF T-CELL FORMATION, I.E., IMMUNOSUPPRESSANTS; TRANSPLANT REJECTION; AUTOIMMUNE DISEASES, E.G., RHEUMATOID DISEASES, PSORIASIS, DERMATITIS, CROHN'S DISEASE, UVEITIS; | NOVARTIS AG (CH) | 2001-01-16 | — | — | US | disclosed |
| US-6043365-A | REACTING BIARYL OR CARBOCYCLIC OR HETEROCYCLIC ISOPROPYL NITRILE DERIVATIVE WITH A LOWER ALKYL ESTER OF FORMIC ACID, CONDENSING THE INTERMEDIATE FORMED WITH AN AMINOALKYL ESTER TO OBTAIN INTERMEDIATE, CYCLIZING AND CONDENSING | NOVARTIS AG (CH) | 2000-03-28 | — | — | US | disclosed |
| EP-0986563-A1 | 2-AMINO-7-(1-SUBSTITUTED-2-HYDROXYETHYL)-3,5-DIHYDRO-PYRROLO 3,2-D]PYRIMIDIN-4-ONES | Novartis AG (CH) | 2000-03-22 | — | — | EP | disclosed |
| WO-1998054185-A1 | 2-AMINO-7-(1-SUBSTITUTED-2-HYDROXYETHYL)-3,5-DIHYDRO-PYRROLO[3,2-D]PYRIMIDIN-4-ONES | NOVARTIS AG (CH) | 1998-12-03 | — | — | WO | disclosed |