Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 8/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | RHEB | Q15382 | 1/20 | 0.32 |
| ▸ | LSS | P48449 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.32 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7873762 | 0.91 | SCN9A (0.37) | SLC6A4SLC6A2SCN9ANR3C1FFAR1 | |
| SCHEMBL7873817 | 0.91 | SLC6A4 (0.37) | SLC6A4SLC6A2SCN9ASLC6A3BRAF | |
| SCHEMBL7877633 | 0.91 | SLC6A2 (0.36) | SLC6A4SLC6A2ROCK2SCN9ABRAF | |
| SCHEMBL7880732 | 0.90 | FFAR1 (0.35) | SLC6A4SLC6A2SCN9AFFAR1RHEB | |
| SCHEMBL7877971 | 0.89 | RXRA (0.37) | SLC6A4SLC6A2ROCK2FFAR1RHEB | |
| SCHEMBL7882026 | 0.87 | SLC6A4 (0.43) | SLC6A4SLC6A2ROCK2SLC6A3HTR2A | |
| SCHEMBL7880924 | 0.87 | FFAR1 (0.36) | SLC6A4SLC6A2FFAR1RHEBBRAF | |
| Hydrochloric Acid SCHEMBL7881837 | 0.86 | SLC6A4 (0.43) | SLC6A4SLC6A2ROCK2SLC6A3HTR2A | |
| Hydrochloric Acid SCHEMBL7881497 | 0.86 | FFAR1 (0.36) | SLC6A4SLC6A2FFAR1RHEBBRAF | |
| SCHEMBL7882375 | 0.86 | FFAR1 (0.39) | FFAR1RHEBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248772-B1 | HYPOTENSIVE AGENTS; ANTIARRHYTHMIA AGENTS; ANTIDIABETIC AGENTS; ANTIPROLIFERATIVE AGENTS | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2001-06-19 | — | — | US | disclosed |
| US-6169107-B1 | USEFUL FOR THE TREATMENT AND PREVENTION OF DISEASES CAUSED BY INCREASED SODIUM/PROTON (NA.SUP.+ /H.SUP.+) EXCHANGER ACTIVITY, FOR EXAMPLE, HYPERTENSION, ARRHYTHMIA, ANGINA PECTORIS, CARDIAC HYPERTROPHY, DIABETES MELLITUS | SUMITOMO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-0708091-A2 | Indoloylguanidine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-04-24 | — | — | EP | disclosed |