Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | AHR | P35869 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | BPTF | Q12830 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29695587 | 0.82 | TDP1 (0.73) | TDP1AHRMAPK1L3MBTL1MEN1 | |
| Hydrochloric Acid SCHEMBL7880082 | 0.81 | MAPT (0.55) | PRKCQMAPK1L3MBTL1MEN1KMT2A | |
| SCHEMBL28853179 | 0.77 | TDP1 (0.62) | TDP1MAPK1L3MBTL1MEN1KMT2A | |
| SCHEMBL7880687 | 0.76 | BRD4 (0.43) | TDP1PRKCQL3MBTL1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7876724 | 0.75 | BRD4 (0.43) | TDP1PRKCQL3MBTL1MEN1KMT2A | |
| SCHEMBL7880710 | 0.74 | BRD4 (0.42) | TDP1PRKCQL3MBTL1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5424147 | 0.74 | GSK3B (0.55) | TDP1PRKCQL3MBTL1MEN1KMT2A | |
| SCHEMBL7883285 | 0.74 | MAOA (0.48) | PRKCQMAPK1MEN1KMT2ARAB9A | |
| SCHEMBL7880690 | 0.73 | BRD4 (0.39) | TDP1PRKCQMAPK1L3MBTL1MEN1 | |
| Hydrochloric Acid SCHEMBL7876717 | 0.73 | BRD4 (0.41) | TDP1PRKCQL3MBTL1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1244542-C | Aromatic amine derivatives having NOS inhibitory effect | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2006-03-08 | — | — | CN | disclosed |
| US-6331553-B1 | INHIBITORS OF NITRIC OXIDE SYNTHASE; TREATING CEREBROVASCULAR DISEASES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2001-12-18 | — | — | US | disclosed |
| EP-0949242-A1 | AROMATIC AMINE DERIVATIVES HAVING NOS INHIBITORY EFFECT | Chugai Seiyaku Kabushiki Kaisha (JP) | 1999-10-13 | — | — | EP | disclosed |