Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 10/20 | 0.82 |
| ▸ | PDE7B | Q9NP56 | 5/20 | 0.76 |
| ▸ | PDE8A | O60658 | 3/20 | 0.76 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30837831 | 0.92 | PDE7A (0.83) | PDE7APDE7BPDE8AMEN1MAPT | |
| SCHEMBL100713 | 0.92 | PDE7A (0.83) | PDE7APDE7BPDE8AMEN1MAPT | |
| SCHEMBL99998 | 0.92 | PDE7A (0.88) | PDE7APDE7BPDE8AMEN1MAPT | |
| SCHEMBL100114 | 0.90 | PDE7A (0.80) | PDE7APDE7BPDE8AMEN1MAPT | |
| SCHEMBL30837972 | 0.90 | PDE7A (1.00) | PDE7APDE7BPDE8AMEN1MAPT | |
| SCHEMBL100698 | 0.90 | PDE7A (1.00) | PDE7APDE7BPDE8AMEN1MAPT | |
| SCHEMBL100608 | 0.90 | PDE7A (1.00) | PDE7APDE7BPDE8AMEN1MAPT | |
| SCHEMBL30837886 | 0.90 | PDE7A (1.00) | PDE7APDE7BPDE8AMEN1MAPT | |
| SCHEMBL99985 | 0.90 | PDE7A (0.80) | PDE7APDE7BPDE8AMEN1MAPT | |
| SCHEMBL30837824 | 0.90 | PDE7A (0.80) | PDE7APDE7BPDE8AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411009-B1 | Therapeutic uses of quinazolinedione derivatives | SANOFI SA (FR) | 2013-03-20 | — | — | EP | disclosed |
| WO-2010116090-A1 | THERAPEUTIC APPLICATIONS IN THE CARDIOVASCULAR FIELD OF QUINAZOLINEDIONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2010-10-14 | — | — | WO | disclosed |
| WO-2010109148-A1 | THERAPEUTIC USES OF QUINAZOLINEDIONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2010-09-30 | — | — | WO | disclosed |
| WO-2009077680-A1 | QUINAZOLINEDIONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USES THEREOF | SANOFI-AVENTIS (FR) | 2009-06-25 | — | — | WO | disclosed |