Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 1/20 | 0.72 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.72 |
| ▸ | PLK4 | O00444 | 3/20 | 0.69 |
| ▸ | PLK1 | P53350 | 3/20 | 0.69 |
| ▸ | RET | P07949 | 3/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | FLT3 | P36888 | 4/20 | 0.59 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.59 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.59 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.59 |
| ▸ | ABL1 | P00519 | 1/20 | 0.59 |
| ▸ | LCK | P06239 | 1/20 | 0.59 |
| ▸ | FYN | P06241 | 1/20 | 0.59 |
| ▸ | CSF1R | P07333 | 1/20 | 0.59 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.59 |
| ▸ | LTK | P29376 | 1/20 | 0.59 |
| ▸ | GRK5 | P34947 | 1/20 | 0.59 |
| ▸ | KDR | P35968 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8300232 | 1.00 | MAP3K7 (0.72) | MAP3K7TAB1PLK4PLK1RET | |
| SCHEMBL7872417 | 0.83 | MAP3K7 (0.62) | MAP3K7TAB1PLK4PLK1RET | |
| SCHEMBL8300100 | 0.83 | MAP3K7 (0.62) | MAP3K7TAB1PLK4PLK1RET | |
| SCHEMBL5476218 | 0.82 | PLK4 (1.00) | MAP3K7TAB1PLK4PLK1RET | |
| SCHEMBL16442337 | 0.82 | PLK4 (1.00) | MAP3K7TAB1PLK4PLK1RET | |
| SCHEMBL5476220 | 0.82 | PLK4 (1.00) | MAP3K7TAB1PLK4PLK1RET | |
| SCHEMBL7872431 | 0.81 | MAP3K7 (0.69) | MAP3K7TAB1PLK4PLK1RET | |
| SCHEMBL8291297 | 0.81 | MAP3K7 (0.69) | MAP3K7TAB1PLK4PLK1RET | |
| SCHEMBL3371607 | 0.80 | PLK4 (0.74) | MAP3K7TAB1PLK4PLK1RET | |
| SCHEMBL5472949 | 0.80 | PLK4 (0.74) | MAP3K7TAB1PLK4PLK1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0684820-B1 | BIOLOGICALLY ACTIVE 3-SUBSTITUTED OXINDOLE DERIVATIVES USEFUL AS ANTI-ANGIOGENIC AGENTS | PHARMACIA & UPJOHN SPA (IT) | 2001-08-16 | — | — | EP | claimed |
| EP-0662473-B1 | 2-Oxindole derivatives as tyrosine kinase inhibitors | PHARMACIA & UPJOHN SPA (IT) | 1999-09-01 | — | — | EP | claimed |
| EP-0662473-A1 | 2-Oxindole derivatives as tyrosine kinase inhibitors | PHARMACIA S.p.A. (IT) | 1995-07-12 | — | — | EP | claimed |
| US-5374652-A | Substituted naphthylmethylene- or tetrahydronaphthylmethylene-derivatives of 2-oxoindole | FARMITALIA CARLO ERBA S R L (IT) | 1994-12-20 | — | — | US | claimed |
| EP-0470221-A1 | NEW ARYL- AND HETEROARYLETHENYLENE DERIVATIVES AND PROCESS FOR THEIR PREPARATION. | ERBA CARLO SPA (IT) | 1992-02-12 | — | — | EP | claimed |
| WO-1991013055-A2 | NEW ARYL- AND HETEROARYLETHENYLENE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.R.L. (IT) | 1991-09-05 | — | — | WO | claimed |
| EP-0662473-B1 | 2-Oxindole derivatives as tyrosine kinase inhibitors | PHARMACIA & UPJOHN SPA (IT) | 1999-09-01 | — | — | EP | disclosed |
| US-5627207-A | CANCER | FARMITALIA CARLO ERBA S R L (IT) | 1997-05-06 | — | — | US | disclosed |
| US-5488057-A | ENZYME INHIBITORS AND ANTICARCINOGENIC AGENTS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1996-01-30 | — | — | US | disclosed |
| EP-0662473-A1 | 2-Oxindole derivatives as tyrosine kinase inhibitors | PHARMACIA S.p.A. (IT) | 1995-07-12 | — | — | EP | disclosed |
| US-5374652-A | Substituted naphthylmethylene- or tetrahydronaphthylmethylene-derivatives of 2-oxoindole | FARMITALIA CARLO ERBA S R L (IT) | 1994-12-20 | — | — | US | disclosed |
| WO-1991013055-A2 | NEW ARYL- AND HETEROARYLETHENYLENE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.R.L. (IT) | 1991-09-05 | — | — | WO | disclosed |