Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 1/20 | 0.62 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.62 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.61 |
| ▸ | PLK4 | O00444 | 2/20 | 0.59 |
| ▸ | PLK1 | P53350 | 2/20 | 0.59 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | IDO1 | P14902 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 4/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7872417 | 1.00 | MAP3K7 (0.62) | MAP3K7TAB1CHEK1PLK4PLK1 | |
| SCHEMBL5201417 | 0.91 | PLK4 (0.62) | MAP3K7TAB1CHEK1PLK4PLK1 | |
| SCHEMBL8099054 | 0.87 | PDPK1 (0.50) | MAP3K7TAB1CHEK1PLK4PLK1 | |
| SCHEMBL8319397 | 0.87 | RAF1 (0.60) | MAP3K7TAB1CHEK1PLK4PLK1 | |
| SCHEMBL8099022 | 0.85 | FLT3 (0.53) | MAP3K7TAB1CHEK1NPC1KDM4E | |
| SCHEMBL8099485 | 0.85 | DHFR (0.52) | MAP3K7TAB1CHEK1PLK4PLK1 | |
| SCHEMBL8099047 | 0.85 | PLK4 (0.56) | MAP3K7TAB1CHEK1PLK4PLK1 | |
| SCHEMBL8348594 | 0.85 | KDM4E (0.52) | MAP3K7TAB1CHEK1PLK4PLK1 | |
| SCHEMBL8300232 | 0.83 | MAP3K7 (0.72) | MAP3K7TAB1CHEK1PLK4PLK1 | |
| SCHEMBL7878474 | 0.83 | MAP3K7 (0.72) | MAP3K7TAB1CHEK1PLK4PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0662473-B1 | 2-Oxindole derivatives as tyrosine kinase inhibitors | PHARMACIA & UPJOHN SPA (IT) | 1999-09-01 | — | — | EP | claimed |