SCHEMBL7878656

SCHEMBL7878656

CCOC(=O)c1cccc([N+](=O)[O-])c1OCC

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.53
SMN1; SMN2 Q16637 3/20 0.53
GAA P10253 1/20 0.53
TSHR P16473 2/20 0.51
MAPT P10636 6/20 0.50
RAB9A P51151 2/20 0.48
LMNA P02545 2/20 0.48
GALR2 O43603 1/20 0.48
MITF O75030 1/20 0.48
POLB P06746 1/20 0.48
HSP90AA1 P07900 1/20 0.48
HPGD P15428 1/20 0.48
XBP1 P17861 1/20 0.48
CCR6 P51684 1/20 0.48
NPSR1 Q6W5P4 1/20 0.48
MAPK1 P28482 3/20 0.47
NPC1 O15118 1/20 0.47
NFKB1 P19838 1/20 0.47
NFKB2 Q00653 1/20 0.47
RELA Q04206 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5427764 0.89 ALDH1A1 (0.53) ALDH1A1SMN1; SMN2GAATSHRMAPT
SCHEMBL23779237 0.85 TSHR (0.58) ALDH1A1SMN1; SMN2GAATSHRMAPT
SCHEMBL31226693 0.84 MAPT (0.46) ALDH1A1SMN1; SMN2GAATSHRMAPT
SCHEMBL16960779 0.84 MAPT (0.48) ALDH1A1SMN1; SMN2GAATSHRMAPT
SCHEMBL3481205 0.84 TSHR (0.64) ALDH1A1SMN1; SMN2GAATSHRMAPT
SCHEMBL7880679 0.83 ALDH1A1 (0.55) ALDH1A1SMN1; SMN2GAATSHRMAPT
SCHEMBL1523174 0.83 ALDH1A1 (0.67) ALDH1A1SMN1; SMN2GAATSHRMAPT
SCHEMBL11464655 0.82 ALDH1A1 (0.57) ALDH1A1SMN1; SMN2GAATSHRMAPT
SCHEMBL1611630 0.82 ALDH1A1 (0.55) ALDH1A1SMN1; SMN2GAATSHRMAPT
SCHEMBL16957783 0.82 RECQL (0.44) ALDH1A1SMN1; SMN2GAATSHRMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6331553-B1 INHIBITORS OF NITRIC OXIDE SYNTHASE; TREATING CEREBROVASCULAR DISEASES CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2001-12-18 US disclosed
EP-0949242-A1 AROMATIC AMINE DERIVATIVES HAVING NOS INHIBITORY EFFECT Chugai Seiyaku Kabushiki Kaisha (JP) 1999-10-13 EP disclosed