Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 18/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7880694 | 0.88 | MAPK1 (0.51) | MAPK1RPS6KA3 | |
| SCHEMBL7885989 | 0.86 | MAPK1 (0.47) | MAPK1CHRM4RPS6KA3 | |
| SCHEMBL10236328 | 0.82 | MAPK1 (0.64) | MAPK1RPS6KA3 | |
| SCHEMBL7880707 | 0.80 | MAPK1 (0.44) | MAPK1RPS6KA3 | |
| SCHEMBL10236186 | 0.78 | MAPK1 (0.71) | MAPK1RPS6KA3 | |
| SCHEMBL7874409 | 0.78 | ALDH1A1 (0.47) | MAPK1 | |
| SCHEMBL13092870 | 0.76 | MAPK1 (0.39) | MAPK1RPS6KA3 | |
| SCHEMBL13093050 | 0.76 | MAPK1 (0.44) | MAPK1CHRM4RPS6KA3 | |
| SCHEMBL7883180 | 0.76 | MAPK1 (0.46) | MAPK1RPS6KA3 | |
| SCHEMBL7880698 | 0.73 | CHRM4 (0.44) | MAPK1CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |