Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.71 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | G6PD | P11413 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8655901 | 1.00 | ALDH1A1 (0.71) | ALDH1A1CYP2C19CYP3A4CYP2C9MCHR1 | |
| SCHEMBL7220819 | 0.98 | ALDH1A1 (0.74) | ALDH1A1CYP2C19CYP3A4CYP2C9MCHR1 | |
| SCHEMBL4391249 | 0.92 | ALDH1A1 (0.77) | ALDH1A1CYP2C19CYP3A4CYP2C9MCHR1 | |
| SCHEMBL8971186 | 0.90 | ALDH1A1 (0.87) | ALDH1A1CYP2C19CYP3A4CYP2C9MCHR1 | |
| SCHEMBL8971703 | 0.90 | ALDH1A1 (0.87) | ALDH1A1CYP2C19CYP3A4CYP2C9MCHR1 | |
| SCHEMBL8970703 | 0.90 | ALDH1A1 (0.87) | ALDH1A1CYP2C19CYP3A4CYP2C9MCHR1 | |
| SCHEMBL8971430 | 0.90 | ALDH1A1 (0.87) | ALDH1A1CYP2C19CYP3A4CYP2C9MCHR1 | |
| SCHEMBL8970657 | 0.90 | ALDH1A1 (0.87) | ALDH1A1CYP2C19CYP3A4CYP2C9MCHR1 | |
| SCHEMBL8971393 | 0.90 | ALDH1A1 (0.87) | ALDH1A1CYP2C19CYP3A4CYP2C9MCHR1 | |
| SCHEMBL4001371 | 0.90 | ALDH1A1 (0.87) | ALDH1A1CYP2C19CYP3A4CYP2C9MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0573218-B1 | 4-Carboxyimidazoles as angiotensin II antagonists and their thrapeutic use | SANKYO CO (JP) | 2001-03-07 | — | — | EP | disclosed |
| CN-1051766-C | Angiotensin II antagonist imidazole derivatives, their preparation and their theapeutic use | SANKYO CO (JP) | 2000-04-26 | — | — | CN | disclosed |
| US-5646171-A | HYPOTENSIVE AGENTS | SANKYO COMPANY, LIMITED (JP) | 1997-07-08 | — | — | US | disclosed |
| US-5616599-A | HYPOTENSIVE AGENTS FOR CARDIOVASCULAR DISORDER | SANKYO COMPANY, LIMITED (JP) | 1997-04-01 | — | — | US | disclosed |
| CN-1085896-A | The Angiotensin II antagonist imidazole derivatives, their preparation and therepic use thereof | SANKYO CO (JP) | 1994-04-27 | — | — | CN | disclosed |
| EP-0573218-A2 | 4-Carboxyimidazoles as angiotensin II antagonists and their thrapeutic use | SANKYO COMPANY LIMITED (JP) | 1993-12-08 | — | — | EP | disclosed |