Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 14/20 | 0.72 |
| ▸ | PFKFB4 | Q16877 | 12/20 | 0.72 |
| ▸ | CMA1 | P23946 | 5/20 | 0.57 |
| ▸ | TCF4 | P15884 | 1/20 | 0.50 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL787986 | 0.84 | PFKFB3 (1.00) | PFKFB3PFKFB4CMA1TCF4CTNNB1 | |
| SCHEMBL787869 | 0.84 | PFKFB3 (1.00) | PFKFB3PFKFB4CMA1 | |
| SCHEMBL788203 | 0.84 | PFKFB3 (0.77) | PFKFB3PFKFB4CMA1TCF4CTNNB1 | |
| SCHEMBL787888 | 0.82 | PFKFB3 (1.00) | PFKFB3PFKFB4CMA1 | |
| SCHEMBL788389 | 0.80 | PFKFB3 (0.56) | PFKFB3PFKFB4TCF4CTNNB1 | |
| SCHEMBL788429 | 0.79 | PFKFB3 (0.87) | PFKFB3PFKFB4CMA1 | |
| SCHEMBL788154 | 0.79 | PFKFB3 (0.83) | PFKFB3PFKFB4CMA1 | |
| SCHEMBL787883 | 0.79 | PFKFB3 (0.69) | PFKFB3PFKFB4CMA1 | |
| SCHEMBL788058 | 0.79 | PFKFB3 (1.00) | PFKFB3PFKFB4CMA1 | |
| SCHEMBL806139 | 0.78 | PFKFB3 (0.84) | PFKFB3PFKFB4CMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616450-A2 | SULFONAMIDE COMPOUNDS | Kancera AB (SE) | 2013-07-24 | — | — | EP | claimed |
| WO-2012035171-A2 | NEW COMPOUNDS | KANCERA AB (SE) | 2012-03-22 | — | — | WO | claimed |
| WO-2020080979-A1 | PFKFB3 INHIBITORS AND THEIR USES | GERO DISCOVERY LIMITED LIABILITY COMPANY (RU) | 2020-04-23 | — | — | WO | disclosed |