Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 8/20 | 0.56 |
| ▸ | TCF4 | P15884 | 2/20 | 0.49 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PFKFB4 | Q16877 | 6/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.42 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL788388 | 0.82 | PFKFB3 (0.81) | PFKFB3TCF4CTNNB1POLBPFKFB4 | |
| SCHEMBL787889 | 0.80 | PFKFB3 (0.72) | PFKFB3TCF4CTNNB1PFKFB4 | |
| SCHEMBL788018 | 0.72 | PFKFB3 (1.00) | PFKFB3POLBPFKFB4SMN1; SMN2PTPN1 | |
| SCHEMBL1696378 | 0.69 | CYP4F2 (0.76) | MAPTHIF1ASMN1; SMN2 | |
| SCHEMBL4187307 | 0.69 | POLB (0.72) | PFKFB3TCF4CTNNB1POLBPFKFB4 | |
| SCHEMBL2896310 | 0.68 | TCF4 (0.73) | PFKFB3TCF4CTNNB1POLBPFKFB4 | |
| SCHEMBL4116745 | 0.68 | RAB9A (0.67) | TP53MAPTHIF1ASMN1; SMN2 | |
| SCHEMBL16116948 | 0.67 | TCF4 (1.00) | TCF4CTNNB1POLBMAPTLMNA | |
| SCHEMBL31253926 | 0.67 | TCF4 (1.00) | TCF4CTNNB1POLBMAPTLMNA | |
| SCHEMBL31681336 | 0.67 | POLB (0.69) | PFKFB3TCF4CTNNB1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616450-A2 | SULFONAMIDE COMPOUNDS | Kancera AB (SE) | 2013-07-24 | — | — | EP | claimed |
| WO-2012035171-A2 | NEW COMPOUNDS | KANCERA AB (SE) | 2012-03-22 | — | — | WO | claimed |
| WO-2020080979-A1 | PFKFB3 INHIBITORS AND THEIR USES | GERO DISCOVERY LIMITED LIABILITY COMPANY (RU) | 2020-04-23 | — | — | WO | disclosed |
| EP-2616450-A2 | SULFONAMIDE COMPOUNDS | Kancera AB (SE) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012035171-A2 | NEW COMPOUNDS | KANCERA AB (SE) | 2012-03-22 | — | — | WO | disclosed |