Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.34 |
| ▸ | RET | P07949 | 7/20 | 0.34 |
| ▸ | KIF5B | P33176 | 7/20 | 0.34 |
| ▸ | LCK | P06239 | 3/20 | 0.34 |
| ▸ | CSF1R | P07333 | 3/20 | 0.34 |
| ▸ | LYN | P07948 | 3/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.34 |
| ▸ | FGR | P09769 | 3/20 | 0.34 |
| ▸ | KIT | P10721 | 3/20 | 0.34 |
| ▸ | SRC | P12931 | 3/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.34 |
| ▸ | BLK | P51451 | 3/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.34 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.34 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10237401 | 0.92 | CHEK1 (0.40) | KDRRETKIF5BLCKCSF1R | |
| SCHEMBL7874817 | 0.84 | MTOR (0.44) | KDRRETKIF5BFGFR1NTRK3 | |
| SCHEMBL7874827 | 0.84 | MTOR (0.38) | KDRMTORRPTORMLST8NPC1 | |
| SCHEMBL7882519 | 0.83 | CHEK1 (0.36) | MTORRPTORMLST8NPC1RAB9A | |
| SCHEMBL7882501 | 0.80 | MTOR (0.33) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL7884144 | 0.78 | KDM4E (0.44) | MTORRPTORMLST8NPC1RAB9A | |
| SCHEMBL7883695 | 0.78 | CCNA2 (0.42) | RETMTORRPTORMLST8SYK | |
| SCHEMBL7878823 | 0.76 | MTOR (0.45) | MTORRPTORMLST8NPC1RAB9A | |
| SCHEMBL595379 | 0.76 | MTOR (0.43) | KDRRETKIF5BLCKCSF1R | |
| SCHEMBL2686451 | 0.76 | MTOR (0.43) | KDRRETKIF5BLCKCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |