Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 3/20 | 0.33 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.33 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 8/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.32 |
| ▸ | CDK2 | P24941 | 8/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 8/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.32 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10237391 | 0.85 | CHEK1 (0.43) | CHEK1CCNA2CDK2CCNA1ALOX5AP | |
| SCHEMBL7883677 | 0.84 | ALOX5AP (0.37) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL7874817 | 0.83 | MTOR (0.44) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL7882900 | 0.80 | CHEK1 (0.37) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL2679739 | 0.80 | CHEK1 (0.37) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL584686 | 0.80 | CHEK1 (0.37) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL2685574 | 0.80 | CHEK1 (0.37) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL10237382 | 0.80 | CHEK1 (0.44) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL7879137 | 0.80 | KDR (0.34) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL7874827 | 0.79 | MTOR (0.38) | MTORRPTORMLST8CHEK1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |