Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR2 | O15552 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | CIT | O14578 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13229741 | 0.83 | FFAR2 (0.57) | FFAR2RAB9ANPC1TP53MAPT | |
| SCHEMBL21580323 | 0.82 | FFAR2 (0.56) | FFAR2RAB9ANPC1TP53MAPT | |
| Hydrochloric Acid SCHEMBL5042270 | 0.81 | FFAR2 (0.55) | FFAR2RAB9ANPC1TP53MAPT | |
| SCHEMBL13057030 | 0.78 | FFAR2 (0.58) | FFAR2RAB9ANPC1TP53MAPT | |
| SCHEMBL7117272 | 0.78 | POLB (0.57) | FFAR2RAB9ANPC1TP53SMN1; SMN2 | |
| SCHEMBL1254966 | 0.78 | POLB (0.57) | FFAR2RAB9ANPC1TP53SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5040568 | 0.77 | GAA (0.59) | FFAR2RAB9ANPC1TP53MAPT | |
| SCHEMBL1067999 | 0.76 | AAK1 (0.53) | FFAR2RAB9ANPC1SMN1; SMN2GAA | |
| SCHEMBL20473204 | 0.76 | AAK1 (0.53) | FFAR2RAB9ANPC1SMN1; SMN2GAA | |
| SCHEMBL7868098 | 0.75 | FFAR2 (0.56) | FFAR2RAB9ANPC1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |