Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 12/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 11/20 | 0.37 |
| ▸ | CDK2 | P24941 | 11/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 11/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.33 |
| ▸ | STK10 | O94804 | 1/20 | 0.33 |
| ▸ | LATS1 | O95835 | 1/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | MARK3 | P27448 | 1/20 | 0.33 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.33 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10239304 | 0.95 | MET (0.38) | CHEK1CCNA2CDK2CCNA1MET | |
| SCHEMBL10239296 | 0.95 | MET (0.38) | CHEK1CCNA2CDK2CCNA1MET | |
| SCHEMBL10235210 | 0.92 | CHEK1 (0.38) | CHEK1CCNA2CDK2CCNA1TGFBR1 | |
| SCHEMBL7874894 | 0.90 | MAP4K4 (0.41) | CHEK1CCNA2CDK2CCNA1MET | |
| SCHEMBL10235196 | 0.87 | CHEK1 (0.39) | CHEK1CCNA2CDK2CCNA1MET | |
| SCHEMBL10235211 | 0.87 | CHEK1 (0.39) | CHEK1CCNA2CDK2CCNA1MET | |
| SCHEMBL7884549 | 0.86 | MAP4K4 (0.38) | KCNH2METMAP4K4 | |
| SCHEMBL10239234 | 0.85 | CHEK1 (0.48) | CHEK1CCNA2CDK2CCNA1MET | |
| SCHEMBL10239077 | 0.84 | OPRL1 (0.36) | CHEK1CCNA2CDK2CCNA1MET | |
| SCHEMBL10239220 | 0.84 | OPRL1 (0.36) | CHEK1CCNA2CDK2CCNA1MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |