Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.46 |
| ▸ | TYR | P14679 | 1/20 | 0.46 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | JUN | P05412 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL823582 | 0.88 | SMN1; SMN2 (0.57) | SMN1; SMN2ALDH1A1KDM4EPOLBLMNA | |
| SCHEMBL8624080 | 0.86 | ERN1 (0.59) | ERN1TRIM24TYRTRIM33ALDH1A1 | |
| SCHEMBL12264144 | 0.82 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1KDM4EPOLBLMNA | |
| SCHEMBL10307884 | 0.81 | POLB (0.45) | SMN1; SMN2ALDH1A1KDM4EPOLBLMNA | |
| SCHEMBL29955976 | 0.80 | TRIM24 (0.61) | ERN1SMN1; SMN2TRIM24TYRTRIM33 | |
| SCHEMBL548189 | 0.80 | TRIM24 (0.61) | ERN1SMN1; SMN2TRIM24TYRTRIM33 | |
| SCHEMBL4733806 | 0.80 | ERN1 (0.61) | ERN1SMN1; SMN2TRIM24TYRTRIM33 | |
| SCHEMBL11777736 | 0.77 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1KDM4EPOLBLMNA | |
| SCHEMBL30138984 | 0.76 | ERN1 (0.56) | ERN1TRIM24TYRTRIM33ALDH1A1 | |
| SCHEMBL826392 | 0.75 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1KDM4EPOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120382-A1 | COMPOUNDS AND METHODS FOR MODULATING ACTIVITY OF CALCIUM RELEASE CHANNELS | STATE OF OREGON BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF PORTLAND STATE UNIVERSITY (US) | 2010-10-21 | — | — | WO | disclosed |