Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 4/20 | 0.58 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.58 |
| ▸ | CDC7 | O00311 | 1/20 | 0.58 |
| ▸ | PLK4 | O00444 | 1/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.58 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.58 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.58 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.58 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.58 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.58 |
| ▸ | PAK4 | O96013 | 1/20 | 0.58 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
| ▸ | INSR | P06213 | 1/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | FYN | P06241 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL298672 | 0.94 | AXL (0.52) | AXLNTRK1DYRK1ACDC7PLK4 | |
| SCHEMBL413558 | 0.90 | AXL (0.58) | AXLNTRK1DYRK1ACDC7PLK4 | |
| SCHEMBL4570623 | 0.89 | AXL (0.57) | AXLNTRK1DYRK1ACDC7PLK4 | |
| SCHEMBL858764 | 0.89 | AXL (0.58) | AXLNTRK1DYRK1ACDC7PLK4 | |
| SCHEMBL858632 | 0.86 | NTRK1 (0.64) | AXLNTRK1DYRK1ACDC7PLK4 | |
| SCHEMBL20086218 | 0.85 | DYRK1A (0.56) | AXLNTRK1DYRK1APDPK1CDK2 | |
| SCHEMBL857559 | 0.85 | KIT (0.54) | AXLNTRK1DYRK1ARIPK1KIT | |
| SCHEMBL298899 | 0.85 | CAMKK2 (0.56) | AXLPLK4RIPK1KITBRAF | |
| SCHEMBL299603 | 0.84 | CYP2C9 (0.53) | AXLNTRK1DYRK1ACDC7PLK4 | |
| SCHEMBL858530 | 0.84 | AXL (0.58) | AXLNTRK1DYRK1ACDC7PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129570-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | PLEXXIKON, INC. (US) | 2010-11-11 | — | — | WO | disclosed |