Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9022145 | 0.87 | KDM4E (0.35) | KDM4ECYP1A2CYP2D6CYP2C19LMNA | |
| SCHEMBL8443854 | 0.84 | KCNH2 (0.44) | CYP2D6CYP2C19ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8447347 | 0.83 | KCNH2 (0.43) | CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL8443490 | 0.78 | CA12 (0.47) | KDM4ELMNAKMT2AALDH1A1HTT | |
| SCHEMBL4899071 | 0.75 | MAPT (0.54) | KDM4ECYP1A2CYP2D6CYP2C19LMNA | |
| SCHEMBL4908756 | 0.74 | MAPT (0.49) | KDM4ECYP1A2CYP2D6CYP2C19LMNA | |
| SCHEMBL4907895 | 0.73 | KDM4E (0.59) | KDM4ECYP1A2CYP2D6CYP2C19LMNA | |
| Butyl Chloride SCHEMBL27485209 | 0.73 | KDM4E (0.56) | KDM4ECYP1A2CYP2D6CYP2C19LMNA | |
| SCHEMBL4909961 | 0.73 | MAPT (0.48) | KDM4ECYP1A2CYP2D6CYP2C19LMNA | |
| SCHEMBL4910266 | 0.73 | MAPT (0.48) | KDM4ECYP1A2CYP2D6CYP2C19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6326500-B1 | ANTIINFLAMMATORY AGENTS; ANTIALLERGENS | ABBOTT LABORATORIES | 2001-12-04 | — | — | US | disclosed |
| US-6215001-B1 | ANTIINFLAMMATORY AGENTS, ANTIASTHMATICS, AND ANTIALLERGENS; SIDE EFFECT REDUCTION | KNOLL AKTIENGESELLSCHAFT (DE) | 2001-04-10 | — | — | US | disclosed |
| US-6031109-A | Phenoxy-, phenylthio-, benzoyl-alkyleneaminoalkylene-imidazole derivatives as therapeutic agents | KNOLL AKTIENGESELLSCHAFT (DE) | 2000-02-29 | — | — | US | disclosed |
| EP-0705251-A1 | IMIDAZOLE DERIVATIVES AS THERAPEUTIC AGENTS | Knoll AG (DE) | 1996-04-10 | — | — | EP | disclosed |
| WO-1995000493-A1 | IMIDAZOLE DERIVATIVES AS THERAPEUTIC AGENTS | KNOLL AG (DE) | 1995-01-05 | — | — | WO | disclosed |