Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 5/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.32 |
| ▸ | F10 | P00742 | 2/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
| ▸ | DRD3 | P35462 | 2/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | PLAU | P00749 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7879704 | 0.92 | IDO1 (0.41) | IDO1SIRT2SIRT1SIRT3TP53 | |
| SCHEMBL7880829 | 0.89 | IDO1 (0.40) | IDO1SIRT2SIRT1SIRT3TP53 | |
| SCHEMBL7882045 | 0.89 | F10 (0.41) | IDO1TP53MAPTLMNATHRB | |
| SCHEMBL7873962 | 0.88 | ST14 (0.38) | IDO1TP53MAPTHRH4FLT3 | |
| SCHEMBL7877539 | 0.88 | SIRT2 (0.42) | IDO1SIRT2SIRT1SIRT3TP53 | |
| SCHEMBL7882004 | 0.87 | PARP1 (0.39) | IDO1SIRT2SIRT1SIRT3HRH4 | |
| SCHEMBL7879419 | 0.85 | IDO1 (0.47) | IDO1SIRT2SIRT1SIRT3TP53 | |
| SCHEMBL7881924 | 0.84 | HTR2A (0.33) | SIRT2SIRT1SIRT3PRMT5WDR77 | |
| SCHEMBL7882084 | 0.84 | SIRT2 (0.39) | IDO1SIRT2SIRT1SIRT3MAPT | |
| SCHEMBL7881241 | 0.83 | IDO1 (0.40) | IDO1SIRT2SIRT1SIRT3TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248772-B1 | HYPOTENSIVE AGENTS; ANTIARRHYTHMIA AGENTS; ANTIDIABETIC AGENTS; ANTIPROLIFERATIVE AGENTS | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2001-06-19 | — | — | US | disclosed |
| US-6169107-B1 | USEFUL FOR THE TREATMENT AND PREVENTION OF DISEASES CAUSED BY INCREASED SODIUM/PROTON (NA.SUP.+ /H.SUP.+) EXCHANGER ACTIVITY, FOR EXAMPLE, HYPERTENSION, ARRHYTHMIA, ANGINA PECTORIS, CARDIAC HYPERTROPHY, DIABETES MELLITUS | SUMITOMO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-0708091-A2 | Indoloylguanidine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-04-24 | — | — | EP | disclosed |