SCHEMBL7882004

SCHEMBL7882004

CN(C(=N)N)C(=O)c1cc2cccc(Oc3cncc(CN4CCCC4)c3)c2[nH]1

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 1/20 0.39
DHODH Q02127 1/20 0.39
SLC6A4 P31645 2/20 0.39
IDO1 P14902 1/20 0.38
SIRT2 Q8IXJ6 1/20 0.36
SIRT1 Q96EB6 1/20 0.36
SIRT3 Q9NTG7 1/20 0.36
HTR2C P28335 1/20 0.36
MCHR1 Q99705 1/20 0.36
DRD2 P14416 3/20 0.35
DRD3 P35462 3/20 0.35
HRH4 Q9H3N8 2/20 0.35
SCN9A Q15858 1/20 0.34
WNT1 P04628 2/20 0.34
DYRK1A Q13627 2/20 0.34
CLK2 P49760 1/20 0.34
CLK3 P49761 1/20 0.34
ROCK2 O75116 2/20 0.34
ROCK1 Q13464 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7877794 0.90 CCR8 (0.41)
SCHEMBL7873775 0.89 CCR8 (0.40) PARP1
SCHEMBL7877531 0.89 DRD2 (0.39) PARP1DRD2DRD3HRH4SCN9A
SCHEMBL7877507 0.88 HRH3 (0.39) PARP1DRD2DRD3HRH4SCN9A
SCHEMBL7879690 0.87 IDO1 (0.42) IDO1SIRT2SIRT1SIRT3DRD2
SCHEMBL7879704 0.86 IDO1 (0.41) PARP1IDO1SIRT2SIRT1SIRT3
SCHEMBL7877795 0.86 DYRK1A (0.35) PARP1DHODHSLC6A4WNT1DYRK1A
SCHEMBL7873734 0.84 DYRK1A (0.34) PARP1DHODHSLC6A4SCN9AWNT1
SCHEMBL7880829 0.84 IDO1 (0.40) IDO1SIRT2SIRT1SIRT3DRD2
SCHEMBL7879616 0.84 SLC6A4 (0.39) SLC6A4IDO1DRD2DRD3HRH4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6248772-B1 HYPOTENSIVE AGENTS; ANTIARRHYTHMIA AGENTS; ANTIDIABETIC AGENTS; ANTIPROLIFERATIVE AGENTS SUMITOMO PHARMACEUTICALS CO., LTD. (JP) 2001-06-19 US disclosed
US-6169107-B1 USEFUL FOR THE TREATMENT AND PREVENTION OF DISEASES CAUSED BY INCREASED SODIUM/PROTON (NA.SUP.+ /H.SUP.+) EXCHANGER ACTIVITY, FOR EXAMPLE, HYPERTENSION, ARRHYTHMIA, ANGINA PECTORIS, CARDIAC HYPERTROPHY, DIABETES MELLITUS SUMITOMO PHARMACEUTICAL CO., LTD. (JP) 2001-01-02 US disclosed
EP-0708091-A2 Indoloylguanidine derivatives SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1996-04-24 EP disclosed