Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 11/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL65431 | 0.90 | REN (0.49) | RENSLC6A4KCNH2SLC6A2CYP3A4 | |
| SCHEMBL65432 | 0.90 | REN (0.49) | RENSLC6A4KCNH2SLC6A2CYP3A4 | |
| SCHEMBL3111265 | 0.80 | REN (0.52) | RENSLC6A4KCNH2SLC6A2CYP3A4 | |
| SCHEMBL78425 | 0.75 | REN (0.43) | RENCYP3A4 | |
| SCHEMBL78744 | 0.74 | REN (0.43) | RENSLC6A4CYP3A4 | |
| SCHEMBL78437 | 0.74 | REN (0.42) | RENSLC6A4CYP3A4 | |
| SCHEMBL79513 | 0.74 | REN (0.46) | RENCYP3A4 | |
| SCHEMBL78486 | 0.71 | CYP3A4 (0.54) | RENCYP3A4 | |
| SCHEMBL38659661 | 0.71 | HSD17B10 (0.37) | — | |
| SCHEMBL10182098 | 0.70 | REN (0.49) | RENSLC6A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |