Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 16/20 | 1.00 |
| ▸ | GRIN2B | Q13224 | 16/20 | 1.00 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18587450 | 0.90 | GRIN1 (0.81) | GRIN1GRIN2BSIGMAR1 | |
| SCHEMBL3393477 | 0.81 | GRIN2B (1.00) | GRIN1GRIN2BSIGMAR1 | |
| SCHEMBL3392267 | 0.81 | GRIN2B (1.00) | GRIN1GRIN2BSIGMAR1 | |
| SCHEMBL3394898 | 0.78 | GRIN1 (1.00) | GRIN1GRIN2BSIGMAR1 | |
| SCHEMBL3396633 | 0.77 | GRIN1 (1.00) | GRIN1GRIN2BSIGMAR1 | |
| SCHEMBL3394795 | 0.77 | GRIN1 (1.00) | GRIN1GRIN2B | |
| SCHEMBL3965085 | 0.76 | GRIN1 (0.61) | GRIN1GRIN2B | |
| SCHEMBL3970687 | 0.76 | GRIN1 (0.61) | GRIN1GRIN2B | |
| SCHEMBL1746466 | 0.76 | GRIN1 (0.61) | GRIN1GRIN2B | |
| SCHEMBL3772950 | 0.74 | GRIN1 (1.00) | GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246331-A1 | NR2B-selective NMDA-receptor antagonists | Westfälische Wilhelms-Universität Münster (DE) | 2010-11-03 | — | — | EP | disclosed |
| WO-2010122134-A1 | NR2B-SELECTIVE NMDA-RECEPTOR ANTAGONISTS | Westfälische Wilhelms Universität Münster (DE) | 2010-10-28 | — | — | WO | disclosed |