Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 9/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7884372 | 0.90 | RHEB (0.39) | RHEBGRIN1KMT2AEIF4A3FLT3 | |
| SCHEMBL7882347 | 0.90 | RHEB (0.39) | RHEBGRIN1EIF4A3FLT3PPARG | |
| SCHEMBL7873184 | 0.89 | RHEB (0.38) | RHEBGRIN1EIF4A3FLT3 | |
| Hydrochloric Acid SCHEMBL7884300 | 0.89 | RHEB (0.38) | RHEBGRIN1KMT2AEIF4A3FLT3 | |
| Hydrochloric Acid SCHEMBL7873497 | 0.89 | RHEB (0.39) | RHEBGRIN1EIF4A3FLT3PPARG | |
| SCHEMBL7873284 | 0.88 | DRD2 (0.41) | RHEB | |
| SCHEMBL7880007 | 0.88 | RHEB (0.42) | RHEBGRIN1KMT2AEIF4A3FLT3 | |
| SCHEMBL7879405 | 0.88 | ST14 (0.41) | RHEBGRIN1KMT2AEIF4A3FLT3 | |
| SCHEMBL7880851 | 0.87 | PPARG (0.40) | RHEBGRIN1KMT2AFLT3MEN1 | |
| Hydrochloric Acid SCHEMBL7881143 | 0.87 | ST14 (0.40) | RHEBGRIN1KMT2AEIF4A3FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248772-B1 | HYPOTENSIVE AGENTS; ANTIARRHYTHMIA AGENTS; ANTIDIABETIC AGENTS; ANTIPROLIFERATIVE AGENTS | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2001-06-19 | — | — | US | disclosed |
| US-6169107-B1 | USEFUL FOR THE TREATMENT AND PREVENTION OF DISEASES CAUSED BY INCREASED SODIUM/PROTON (NA.SUP.+ /H.SUP.+) EXCHANGER ACTIVITY, FOR EXAMPLE, HYPERTENSION, ARRHYTHMIA, ANGINA PECTORIS, CARDIAC HYPERTROPHY, DIABETES MELLITUS | SUMITOMO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-0708091-A2 | Indoloylguanidine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-04-24 | — | — | EP | disclosed |