Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 9/20 | 0.31 |
| ▸ | LOX | P28300 | 8/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.31 |
| ▸ | RHEB | Q15382 | 1/20 | 0.31 |
| ▸ | RAF1 | P04049 | 1/20 | 0.30 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7881238 | 0.92 | KDR (0.33) | LOXL2LOXMAPK8MAPK10RHEB | |
| SCHEMBL7882284 | 0.89 | LOXL2 (0.32) | LOXL2LOX | |
| SCHEMBL7879952 | 0.87 | RHEB (0.35) | RHEBRAF1BRAF | |
| SCHEMBL7877875 | 0.86 | RHEB (0.34) | RHEBRAF1BRAF | |
| SCHEMBL7873654 | 0.86 | RHEB (0.35) | MAPK8MAPK10RHEBRAF1BRAF | |
| SCHEMBL7873681 | 0.85 | KMT2A (0.35) | LOXL2LOX | |
| SCHEMBL7877896 | 0.84 | TLR7 (0.35) | MAPK8MAPK10RAF1BRAF | |
| SCHEMBL7882185 | 0.84 | HRH3 (0.41) | RHEB | |
| SCHEMBL7879968 | 0.84 | RHEB (0.31) | LOXL2LOXRHEB | |
| SCHEMBL7881828 | 0.84 | CLK1 (0.31) | MAPK8MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248772-B1 | HYPOTENSIVE AGENTS; ANTIARRHYTHMIA AGENTS; ANTIDIABETIC AGENTS; ANTIPROLIFERATIVE AGENTS | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2001-06-19 | — | — | US | disclosed |
| US-6169107-B1 | USEFUL FOR THE TREATMENT AND PREVENTION OF DISEASES CAUSED BY INCREASED SODIUM/PROTON (NA.SUP.+ /H.SUP.+) EXCHANGER ACTIVITY, FOR EXAMPLE, HYPERTENSION, ARRHYTHMIA, ANGINA PECTORIS, CARDIAC HYPERTROPHY, DIABETES MELLITUS | SUMITOMO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-0708091-A2 | Indoloylguanidine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-04-24 | — | — | EP | disclosed |