SCHEMBL7880424

SCHEMBL7880424

C[C@H](C(=O)O)[C@@](C)(N)c1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.53
CYP2D6 P10635 1/20 0.53
MAPT P10636 1/20 0.48
KMT2A Q03164 1/20 0.48
KIF11 P52732 10/20 0.45
CYP2C19 P33261 1/20 0.42
HIF1A Q16665 1/20 0.42
PTGS2 P35354 1/20 0.41
HDAC3 O15379 1/20 0.41
HDAC4 P56524 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC7 Q8WUI4 1/20 0.41
HDAC2 Q92769 1/20 0.41
HDAC10 Q969S8 1/20 0.41
HDAC11 Q96DB2 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
HDAC9 Q9UKV0 1/20 0.41
HDAC5 Q9UQL6 1/20 0.41
KCNN4 O15554 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28773023 1.00 CYP1A2 (0.53) CYP1A2CYP2D6MAPTKMT2AKIF11
SCHEMBL28310656 0.86 MAPT (0.52) CYP1A2CYP2D6MAPTKMT2AKIF11
SCHEMBL7732425 0.83 KIF11 (0.41) CYP1A2CYP2D6KMT2AKIF11
Hydrochloric Acid SCHEMBL27858912 0.82 KCNN4 (0.43) CYP1A2CYP2D6MAPTKMT2AKIF11
SCHEMBL4365780 0.79 CYP1A2 (0.47) CYP1A2CYP2D6MAPTKMT2AKIF11
SCHEMBL430340 0.79 CYP1A2 (0.47) CYP1A2CYP2D6MAPTKMT2AKIF11
SCHEMBL13091889 0.79 CYP1A2 (0.50) CYP1A2CYP2D6MAPTKMT2AHIF1A
SCHEMBL20184852 0.78 CYP2D6 (0.46) CYP1A2CYP2D6MAPTKMT2AKIF11
SCHEMBL17582896 0.78 CYP2D6 (0.46) CYP1A2CYP2D6MAPTKMT2AKIF11
SCHEMBL9683891 0.78 CYP2D6 (0.46) CYP1A2CYP2D6MAPTKMT2AKIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6174901-B1 FOR TREATMENT OF RHEUMATOID ARTHRITIS, PAGETS DISEASE, OSTEOPHOROSIS, MULTIPLE MYELOMA, UVEITITIS, ACUTE OR CHRONIC MYELOGENOUS LEUKEMIA, PANCREATIC .BETA. CELL DESTRUCTION, OSTEOARTHRITIS, RHEUMATOID SPONDYLITIS, GOUTY ARTHRITIS ETC. AMGEN INC. 2001-01-16 US disclosed