Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 10/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL600727 | 0.86 | GRM5 (0.42) | GRM5HCRTR1HCRTR2HSD11B1NPC1 | |
| SCHEMBL1974274 | 0.85 | HSD11B1 (0.47) | GRM5HSD11B1NPC1RAB9A | |
| SCHEMBL1974271 | 0.85 | HSD11B1 (0.47) | GRM5HSD11B1NPC1RAB9A | |
| SCHEMBL600581 | 0.84 | GRM5 (0.40) | GRM5HCRTR1HCRTR2HSD11B1NPC1 | |
| SCHEMBL10152590 | 0.83 | USP30 (0.42) | GRM5HCRTR1HCRTR2 | |
| SCHEMBL30795726 | 0.81 | HSD11B1 (0.52) | GRM5HSD11B1NPC1RAB9A | |
| SCHEMBL600170 | 0.81 | HSD11B1 (0.52) | GRM5HSD11B1NPC1RAB9A | |
| SCHEMBL7879774 | 0.81 | GRM5 (0.49) | GRM5HSD11B1 | |
| SCHEMBL599414 | 0.81 | GRM5 (0.49) | GRM5HSD11B1 | |
| SCHEMBL599809 | 0.80 | GRM5 (0.47) | GRM5HCRTR1HCRTR2HSD11B1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120040998-A1 | 2-ALKYL PIPERIDINE MGLUR5 RECEPTOR MODULATORS | MERCER SWATI P (US) | 2012-02-16 | — | — | US | disclosed |
| US-20120040998-A1 | 2-ALKYL PIPERIDINE MGLUR5 RECEPTOR MODULATORS | MERCER SWATI P (US) | 2012-02-16 | — | — | US | disclosed |
| WO-2010124055-A1 | 2-ALKYL PIPERIDINE MGLUR5 RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040998-A1 | 2-ALKYL PIPERIDINE MGLUR5 RECEPTOR MODULATORS | GRM5, GRIK5, GRM2 | GRM5 1/4885HCRTR1 199/4885HCRTR2 102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.