Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
| ▸ | TTR | P02766 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7878632 | 0.87 | LMNA (0.47) | LMNAPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL7880759 | 0.84 | LMNA (0.42) | LMNAPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL7880703 | 0.75 | BRD4 (0.44) | LMNAPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL7878585 | 0.75 | TSHR (0.42) | LMNAPOLBALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL6799074 | 0.74 | LMNA (0.66) | LMNAPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL20721722 | 0.74 | CA12 (0.51) | MEN1KMT2AALDH1A1HTTMAPK1 | |
| SCHEMBL30419946 | 0.74 | CA12 (0.51) | MEN1KMT2AALDH1A1HTTMAPK1 | |
| SCHEMBL3618566 | 0.73 | KCNN4 (0.39) | MEN1KMT2AALDH1A1CYP3A4PTGS1 | |
| SCHEMBL6797385 | 0.72 | ROCK1 (0.60) | LMNAPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL6793593 | 0.72 | ABCG2 (0.57) | LMNAPOLBMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331553-B1 | INHIBITORS OF NITRIC OXIDE SYNTHASE; TREATING CEREBROVASCULAR DISEASES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2001-12-18 | — | — | US | disclosed |
| EP-0949242-A1 | AROMATIC AMINE DERIVATIVES HAVING NOS INHIBITORY EFFECT | Chugai Seiyaku Kabushiki Kaisha (JP) | 1999-10-13 | — | — | EP | disclosed |