Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 6/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 6/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.33 |
| ▸ | WNT1 | P04628 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7879711 | 0.92 | IDO1 (0.40) | IDO1SIRT2SIRT1SIRT3SCN9A | |
| SCHEMBL7881417 | 0.86 | DYRK1A (0.33) | SCN9ADYRK1AWNT1 | |
| SCHEMBL7879500 | 0.85 | SCN9A (0.34) | SCN9ADYRK1AWNT1SUCNR1 | |
| SCHEMBL7877543 | 0.84 | SIRT2 (0.41) | IDO1SIRT2SIRT1SIRT3 | |
| SCHEMBL7881874 | 0.84 | DYRK1A (0.36) | IDO1SIRT2SIRT1SIRT3DYRK1A | |
| SCHEMBL7882013 | 0.84 | SLC6A4 (0.40) | IDO1SIRT2SIRT1SIRT3DYRK1A | |
| SCHEMBL7880172 | 0.83 | TP53 (0.35) | IDO1SCN9ATP53MAPTLMNA | |
| SCHEMBL7881928 | 0.83 | IDO1 (0.35) | IDO1SCN9ADYRK1ATP53MAPT | |
| SCHEMBL7873853 | 0.82 | HRH3 (0.39) | IDO1TP53MAPT | |
| SCHEMBL7880204 | 0.82 | LSS (0.36) | IDO1SCN9ATHRBDRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248772-B1 | HYPOTENSIVE AGENTS; ANTIARRHYTHMIA AGENTS; ANTIDIABETIC AGENTS; ANTIPROLIFERATIVE AGENTS | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2001-06-19 | — | — | US | disclosed |
| US-6169107-B1 | USEFUL FOR THE TREATMENT AND PREVENTION OF DISEASES CAUSED BY INCREASED SODIUM/PROTON (NA.SUP.+ /H.SUP.+) EXCHANGER ACTIVITY, FOR EXAMPLE, HYPERTENSION, ARRHYTHMIA, ANGINA PECTORIS, CARDIAC HYPERTROPHY, DIABETES MELLITUS | SUMITOMO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-0708091-A2 | Indoloylguanidine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-04-24 | — | — | EP | disclosed |