Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.35 |
| ▸ | WNT1 | P04628 | 3/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | CLK3 | P49761 | 1/20 | 0.35 |
| ▸ | CCR8 | P51685 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7877798 | 0.90 | CCR8 (0.43) | KMT2ACCR8 | |
| SCHEMBL7873777 | 0.89 | CCR8 (0.42) | CCR8 | |
| SCHEMBL7877534 | 0.89 | MMP1 (0.39) | PARP1DRD2DRD3HRH4 | |
| SCHEMBL7877512 | 0.88 | HRH3 (0.39) | PARP1DRD2DRD3 | |
| SCHEMBL7877802 | 0.86 | DYRK1A (0.35) | SLC6A4PARP1DHODHDYRK1AWNT1 | |
| SCHEMBL7873742 | 0.85 | DYRK1A (0.35) | SLC6A4DYRK1AWNT1CLK2CLK3 | |
| SCHEMBL7879711 | 0.85 | IDO1 (0.40) | SLC6A4PARP1IDO1SIRT2SIRT1 | |
| SCHEMBL7877493 | 0.84 | SLC2A1 (0.36) | SLC6A4PARP1IDO1DRD2DRD3 | |
| SCHEMBL7879623 | 0.84 | SLC6A4 (0.40) | SLC6A4IDO1DRD2DRD3HRH4 | |
| SCHEMBL7880840 | 0.84 | IDO1 (0.39) | IDO1SIRT2SIRT1SIRT3DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248772-B1 | HYPOTENSIVE AGENTS; ANTIARRHYTHMIA AGENTS; ANTIDIABETIC AGENTS; ANTIPROLIFERATIVE AGENTS | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2001-06-19 | — | — | US | disclosed |
| US-6169107-B1 | USEFUL FOR THE TREATMENT AND PREVENTION OF DISEASES CAUSED BY INCREASED SODIUM/PROTON (NA.SUP.+ /H.SUP.+) EXCHANGER ACTIVITY, FOR EXAMPLE, HYPERTENSION, ARRHYTHMIA, ANGINA PECTORIS, CARDIAC HYPERTROPHY, DIABETES MELLITUS | SUMITOMO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-0708091-A2 | Indoloylguanidine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-04-24 | — | — | EP | disclosed |