Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Doxribtimine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 4/20 | 0.73 |
| ▸ | LMNA | P02545 | 3/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.73 |
| ▸ | TK2 | O00142 | 1/20 | 0.71 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.69 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.69 |
| ▸ | ALB | P02768 | 1/20 | 0.67 |
| ▸ | PKM | P14618 | 1/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Doxribtimine SCHEMBL778861 | 1.00 | TK1 (0.73) | TK1LMNASMN1; SMN2TK2ALOX12 | |
| Doxribtimine SCHEMBL4201980 | 1.00 | TK1 (0.73) | TK1LMNASMN1; SMN2TK2ALOX12 | |
| Doxribtimine SCHEMBL542736 | 1.00 | TK1 (0.73) | TK1LMNASMN1; SMN2TK2ALOX12 | |
| Doxribtimine SCHEMBL16189745 | 1.00 | TK1 (0.73) | TK1LMNASMN1; SMN2TK2ALOX12 | |
| Doxribtimine SCHEMBL12286396 | 1.00 | TK1 (0.73) | TK1LMNASMN1; SMN2TK2ALOX12 | |
| Doxribtimine SCHEMBL2922181 | 1.00 | TK1 (0.73) | TK1LMNASMN1; SMN2TK2ALOX12 | |
| Doxribtimine SCHEMBL3437225 | 1.00 | TK1 (0.73) | TK1LMNASMN1; SMN2TK2ALOX12 | |
| Doxribtimine SCHEMBL23486 | 1.00 | TK1 (0.73) | TK1LMNASMN1; SMN2TK2ALOX12 | |
| Doxribtimine SCHEMBL21078835 | 1.00 | TK1 (0.73) | TK1LMNASMN1; SMN2TK2ALOX12 | |
| Doxribtimine SCHEMBL3437224 | 1.00 | TK1 (0.73) | TK1LMNASMN1; SMN2TK2ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0301908-B1 | 1-(3,5-Di-0-benzoyl-2-deoxy-beta-D-threo-pentofuranosyl)thymine and the method of producing the same | CESKOSLOVENSKA AKADEMIE VED (CS) | 1994-02-09 | — | — | EP | claimed |
| EP-0301908-A2 | 1-(3,5-Di-0-benzoyl-2-deoxy-beta-D-threo-pentofuranosyl)thymine and the method of producing the same | Ceskoslovenska akademie ved (CS) | 1989-02-01 | — | — | EP | claimed |
| JP-5059086-A | — | — | None | — | — | JP | disclosed |
| US-20230159922-A1 | MODIFIED OLIGOMERIC COMPOUNDS AND USES THEREOF | IONIS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | US | disclosed |
| US-20230159922-A1 | MODIFIED OLIGOMERIC COMPOUNDS AND USES THEREOF | IONIS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | US | disclosed |
| WO-2021030763-A1 | MODIFIED OLIGOMERIC COMPOUNDS AND USES THEREOF | IONIS PHARMACEUTICALS, INC. (US) | 2021-02-18 | — | — | WO | disclosed |
| WO-2020072991-A1 | MODIFIED OLIGOMERIC COMPOUNDS AND USES THEREOF | IONIS PHARMACEUTICALS, INC. (US) | 2020-04-09 | — | — | WO | disclosed |
| US-9725479-B2 | 5′-end derivatives | IONIS PHARMACEUTICALS, INC. (US) | 2017-08-08 | — | — | US | disclosed |
| US-6329346-B1 | POLYNUCLEOTIDES WITH CARRIERS | ROCHE DIAGNOSTICS GMBH (DE) | 2001-12-11 | — | — | US | disclosed |
| EP-0611373-B1 | OLIGO-2'-DEOXYNUCLEOTIDES AND THEIR USE AS DRUGS WITH AN ANTIVIRAL ACTION | BOEHRINGER MANNHEIM GMBH (DE) | 1997-03-26 | — | — | EP | disclosed |
| US-5376644-A | Viricides | BURROUGHS WELLCOME CO. (US) | 1994-12-27 | — | — | US | disclosed |
| EP-0301908-B1 | 1-(3,5-Di-0-benzoyl-2-deoxy-beta-D-threo-pentofuranosyl)thymine and the method of producing the same | CESKOSLOVENSKA AKADEMIE VED (CS) | 1994-02-09 | — | — | EP | disclosed |
| JP-H0559086-A | PRODUCTION OF 1-(2-DEOXY-BETA-D-THREO-PENTOFURANOSYL) THYMINE DERIVATIVE | NOGUCHI KENKYUSHO | 1993-03-09 | — | — | JP | disclosed |
| US-5070078-A | ADENOVIRUS | BURROUGHS WELLCOME CO. (US) | 1991-12-03 | — | — | US | disclosed |
| WO-1990001036-A1 | NUCLEOSIDE DERIVATIVES | MEDIVIR AB (SE) | 1990-02-08 | — | — | WO | disclosed |
| EP-0301908-A2 | 1-(3,5-Di-0-benzoyl-2-deoxy-beta-D-threo-pentofuranosyl)thymine and the method of producing the same | Ceskoslovenska akademie ved (CS) | 1989-02-01 | — | — | EP | disclosed |
| US-3975374-A | Process for preparing 2-thiouracil nucleosides | THE UPJOHN COMPANY (US) | 1976-08-17 | — | — | US | disclosed |