Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16961950 | 0.88 | RECQL (0.48) | RECQLNPC1RAB9AMAPTKMT2A | |
| SCHEMBL16345006 | 0.87 | RECQL (0.46) | RECQLNPC1RAB9AMAPTKMT2A | |
| SCHEMBL7880793 | 0.85 | RECQL (0.45) | RECQLNPC1RAB9AMAPTKMT2A | |
| SCHEMBL5201436 | 0.81 | ALDH1A1 (0.47) | RECQLNPC1RAB9AMAPTKMT2A | |
| SCHEMBL31347487 | 0.81 | ALDH1A1 (0.47) | RECQLNPC1RAB9AMAPTKMT2A | |
| SCHEMBL28092506 | 0.80 | SMN1; SMN2 (0.51) | RECQLNPC1RAB9AMAPTKMT2A | |
| SCHEMBL27688900 | 0.79 | NPC1 (0.47) | RECQLNPC1RAB9AMAPTKMT2A | |
| SCHEMBL27651187 | 0.78 | TSHR (0.55) | RECQLNPC1RAB9AMAPTKMT2A | |
| SCHEMBL12894176 | 0.78 | MAOB (0.44) | RECQLNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL7872378 | 0.78 | ALDH1A1 (0.41) | RECQLNPC1RAB9AMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331553-B1 | INHIBITORS OF NITRIC OXIDE SYNTHASE; TREATING CEREBROVASCULAR DISEASES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2001-12-18 | — | — | US | disclosed |
| EP-0949242-A1 | AROMATIC AMINE DERIVATIVES HAVING NOS INHIBITORY EFFECT | Chugai Seiyaku Kabushiki Kaisha (JP) | 1999-10-13 | — | — | EP | disclosed |