Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.38 |
| ▸ | NPC1 | O15118 | 7/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.35 |
| ▸ | MEN1 | O00255 | 7/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7880932 | 0.91 | RAB9A (0.38) | RAB9ANPC1KDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL7884506 | 0.89 | RAB9A (0.37) | RAB9ANPC1KDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL10235278 | 0.83 | KDR (0.35) | RAB9ANPC1KDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL10239355 | 0.83 | RAB9A (0.38) | RAB9ANPC1KDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL7879810 | 0.81 | RAB9A (0.36) | RAB9ANPC1KDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL7882322 | 0.79 | RAB9A (0.35) | RAB9ANPC1KDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL7879748 | 0.78 | RAB9A (0.36) | RAB9ANPC1KDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL7882870 | 0.78 | RAB9A (0.36) | RAB9ANPC1KDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL7882334 | 0.77 | RAB9A (0.38) | RAB9ANPC1KDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL7882864 | 0.77 | RAB9A (0.36) | RAB9ANPC1KDM4ESMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |