SCHEMBL7883286

SCHEMBL7883286

CCCOCc1nc(C(C)(C)O)c(C(=O)OCCC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1

nearest known ligand 0.75

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 1/20 0.53
AGTR2 P50052 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7889737 0.99 AGTR1 (0.52) AGTR1AGTR2
SCHEMBL7878411 0.93 AGTR1 (0.58) AGTR1AGTR2
SCHEMBL7889808 0.92 AGTR1 (0.48) AGTR1AGTR2
SCHEMBL7878389 0.90 AGTR1 (0.52) AGTR1AGTR2
Hydrochloric Acid SCHEMBL7887929 0.89 AGTR1 (0.51) AGTR1AGTR2
SCHEMBL7310143 0.86 AGTR1 (0.63) AGTR1AGTR2
SCHEMBL7431029 0.86 AGTR1 (0.53) AGTR1AGTR2
SCHEMBL7886323 0.86 AGTR1 (0.57) AGTR1AGTR2
Hydrochloric Acid SCHEMBL7303166 0.85 AGTR1 (0.62) AGTR1AGTR2
SCHEMBL7883620 0.85 AGTR1 (0.48) AGTR1AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0573218-B1 4-Carboxyimidazoles as angiotensin II antagonists and their thrapeutic use SANKYO CO (JP) 2001-03-07 EP disclosed
CN-1051766-C Angiotensin II antagonist imidazole derivatives, their preparation and their theapeutic use SANKYO CO (JP) 2000-04-26 CN disclosed
US-5646171-A HYPOTENSIVE AGENTS SANKYO COMPANY, LIMITED (JP) 1997-07-08 US disclosed
US-5616599-A HYPOTENSIVE AGENTS FOR CARDIOVASCULAR DISORDER SANKYO COMPANY, LIMITED (JP) 1997-04-01 US disclosed
CN-1085896-A The Angiotensin II antagonist imidazole derivatives, their preparation and therepic use thereof SANKYO CO (JP) 1994-04-27 CN disclosed
EP-0573218-A2 4-Carboxyimidazoles as angiotensin II antagonists and their thrapeutic use SANKYO COMPANY LIMITED (JP) 1993-12-08 EP disclosed