Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 3/20 | 0.44 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7886537 | 0.94 | AGTR1 (0.45) | AGTR1AGTR2 | |
| SCHEMBL7883513 | 0.92 | AGTR1 (0.43) | AGTR1AGTR2 | |
| SCHEMBL8860944 | 0.91 | AGTR1 (0.47) | AGTR1AGTR2 | |
| SCHEMBL7889769 | 0.90 | AGTR1 (0.46) | AGTR1AGTR2 | |
| SCHEMBL7886568 | 0.89 | AGTR1 (0.42) | AGTR1AGTR2 | |
| SCHEMBL668602 | 0.89 | AGTR1 (0.55) | AGTR1AGTR2 | |
| SCHEMBL7889722 | 0.88 | AGTR1 (0.43) | AGTR1AGTR2ABCB11CYP3A4PDE3A | |
| SCHEMBL7878593 | 0.88 | AGTR1 (0.59) | AGTR1AGTR2ABCB11CYP3A4PDE3A | |
| SCHEMBL7300844 | 0.87 | AGTR1 (0.51) | AGTR1AGTR2 | |
| SCHEMBL7889507 | 0.86 | AGTR1 (0.43) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0573218-B1 | 4-Carboxyimidazoles as angiotensin II antagonists and their thrapeutic use | SANKYO CO (JP) | 2001-03-07 | — | — | EP | claimed |
| US-5646171-A | HYPOTENSIVE AGENTS | SANKYO COMPANY, LIMITED (JP) | 1997-07-08 | — | — | US | claimed |
| EP-0573218-B1 | 4-Carboxyimidazoles as angiotensin II antagonists and their thrapeutic use | SANKYO CO (JP) | 2001-03-07 | — | — | EP | disclosed |
| US-5646171-A | HYPOTENSIVE AGENTS | SANKYO COMPANY, LIMITED (JP) | 1997-07-08 | — | — | US | disclosed |
| US-5616599-A | HYPOTENSIVE AGENTS FOR CARDIOVASCULAR DISORDER | SANKYO COMPANY, LIMITED (JP) | 1997-04-01 | — | — | US | disclosed |
| EP-0573218-A2 | 4-Carboxyimidazoles as angiotensin II antagonists and their thrapeutic use | SANKYO COMPANY LIMITED (JP) | 1993-12-08 | — | — | EP | disclosed |