Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 17/20 | 0.56 |
| ▸ | DDB1 | Q16531 | 9/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7874881 | 0.91 | CRBN (0.47) | CRBNDDB1 | |
| SCHEMBL7883858 | 0.90 | CRBN (0.54) | CRBNDDB1 | |
| SCHEMBL16887554 | 0.85 | CRBN (0.61) | CRBNDDB1 | |
| SCHEMBL16886319 | 0.78 | CRBN (0.57) | CRBNDDB1 | |
| SCHEMBL19387964 | 0.78 | CRBN (0.57) | CRBNDDB1 | |
| SCHEMBL16891680 | 0.78 | CRBN (0.59) | CRBNDDB1 | |
| SCHEMBL21150856 | 0.75 | CRBN (0.53) | CRBNDDB1 | |
| SCHEMBL7874125 | 0.74 | CRBN (0.48) | CRBNDDB1 | |
| SCHEMBL2897645 | 0.73 | CRBN (0.65) | CRBNDDB1 | |
| SCHEMBL23076101 | 0.72 | CRBN (0.49) | CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |